PARP (poly (ADP)-ribose polymerase) Inhibitors – Application of Synthetic Lethality Concepts in Cancer Treatments

Authors : Michael Halim

Volume/Issue : Volume 6 - 2021, Issue 2 - February

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The different types and the overwhelming number of cancer cases across the globe have prompted scholars to pursue more effective therapies than traditional treatments. One approach that has demonstrated considerable progress is related to the use of PARP inhibitors. Essentially, PARP inhibitors such as Talazoparib, Olaparib and Rucaparib use a concept of synthetic lethality to kill tumour cells. According to Sebastian (2011) synthetic lethality occurs when a deficiency in one gene expression does not cause cell death while a collection of two or more deficiencies in gene expression leads to cell death. PARP inhibitors exploit this concept to eradicate tumour cells

Keywords : PARP Inhibitors, Talazoparib, Olaparib, Rucaparib


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