Authors : Dr. Venugopal Reddy I.

Volume/Issue : Volume 10 - 2025, Issue 8 - August

Google Scholar : https://tinyurl.com/myc2snzw

Scribd : https://tinyurl.com/v346h6xc

DOI : https://doi.org/10.38124/ijisrt/25aug440

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Abstract : Persistent or recurrent fever without a clear source (fever without focus, FWF) in children under 10 years presents a significant diagnostic and therapeutic challenge, especially in high-burden urban settings like Bangalore. This comprehensive review synthesizes current evidence on the epidemiology, evolving infectious etiologies, diagnostic strategies, and management principles. Emphasizing a structured, tiered approach informed by recent advances in molecular diagnostics and prediction models, it advocates for judicious use of resources and antimicrobial stewardship. The article highlights region-specific factors influencing etiologies, including emerging viral infections, tuberculosis, enteric fever, and rickettsial diseases. This evidence-based framework supports clinical decision-making and interdisciplinary collaboration to optimize patient outcomes and reduce unnecessary interventions.

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