Authors :
N. Chaitanya; Juveriya; Deepthisri; Sumera Neha
Volume/Issue :
Volume 11 - 2026, Issue 3 - March
Google Scholar :
https://tinyurl.com/5akrrz6c
Scribd :
https://tinyurl.com/ycpb38uf
DOI :
https://doi.org/10.38124/ijisrt/26mar1095
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Middle cerebral artery (MCA) Doppler assessment is an important tool in evaluating fetal well-being. Normally,
the MCA demonstrates high-resistance flow, but in hypoxic states it becomes low resistance due to the brain-sparing effect.
In advanced compromise, reverse end-diastolic flow (REDF) may occur, indicating severe pathology. Persistent MCA-REDF
is rare and associated with poor fetal and neonatal outcomes. We report a case of persistent MCA-REDF at 30 weeks of
gestation in a pregnancy complicated by severe pre-eclampsia, resulting in neonatal death despite timely intervention.
Keywords :
MCA Doppler, Reverse End-Diastolic Flow, Pre-eclampsia, Fetal Hypoxia.
References :
- Baschat AA, Gembruch U, Harman CR. The sequence of changes in Doppler and biophysical parameters as severe fetal growth restriction worsens. Ultrasound Obstet Gynecol. 2001.
- Moise KJ. The usefulness of middle cerebral artery Doppler assessment in the treatment of the fetus at risk for anemia. Am J Obstet Gynecol. 2008.
- Respondek M, Woch A, Kaczmarek P, Borowski D. Reversal of diastolic flow in the middle cerebral artery of the fetus. Ultrasound Obstet Gynecol. 2000.
- Nicholaides KH, Rizzo G, Hecher K. Doppler studies in fetal hypoxemia. The Fetal Medicine Foundation; 2002.
- Jakobovits AA. Reverse flow in the fetal middle cerebral artery. Am J Obstet Gynecol. 1997.
- Sepulveda W, Shennan AH, Peek MJ. Reverse end-diastolic flow in the middle cerebral artery: an agonal pattern. Am J Obstet Gynecol. 1996.
- Giancotti A, et al. Reverse end-diastolic flow in a fetus with liver malformation: case report. J Med Case Rep. 2011.
- Society for Maternal-Fetal Medicine. Doppler assessment in fetal growth restriction. Am J Obstet Gynecol. 2012.
- Chainarong N, Suwanrath C, Suksai M. Persistent reversed end-diastolic flow of the MCA: a rare finding. J Clin Ultrasound. 2022.
- Obeidat N, et al. MCA Doppler in congenital hydrocephalus. J Matern Fetal Neonatal Med. 2018.
Middle cerebral artery (MCA) Doppler assessment is an important tool in evaluating fetal well-being. Normally,
the MCA demonstrates high-resistance flow, but in hypoxic states it becomes low resistance due to the brain-sparing effect.
In advanced compromise, reverse end-diastolic flow (REDF) may occur, indicating severe pathology. Persistent MCA-REDF
is rare and associated with poor fetal and neonatal outcomes. We report a case of persistent MCA-REDF at 30 weeks of
gestation in a pregnancy complicated by severe pre-eclampsia, resulting in neonatal death despite timely intervention.
Keywords :
MCA Doppler, Reverse End-Diastolic Flow, Pre-eclampsia, Fetal Hypoxia.