⚠ Official Notice: www.ijisrt.com is the official website of the International Journal of Innovative Science and Research Technology (IJISRT) Journal for research paper submission and publication. Please beware of fake or duplicate websites using the IJISRT name.



Persistent Middle Cerebral Artery Reverse End-Diastolic Flow in Severe Pre-eclampsia: A Rare Case with Adverse Neonatal Outcome


Authors : N. Chaitanya; Juveriya; Deepthisri; Sumera Neha

Volume/Issue : Volume 11 - 2026, Issue 3 - March


Google Scholar : https://tinyurl.com/5akrrz6c

Scribd : https://tinyurl.com/ycpb38uf

DOI : https://doi.org/10.38124/ijisrt/26mar1095

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : Middle cerebral artery (MCA) Doppler assessment is an important tool in evaluating fetal well-being. Normally, the MCA demonstrates high-resistance flow, but in hypoxic states it becomes low resistance due to the brain-sparing effect. In advanced compromise, reverse end-diastolic flow (REDF) may occur, indicating severe pathology. Persistent MCA-REDF is rare and associated with poor fetal and neonatal outcomes. We report a case of persistent MCA-REDF at 30 weeks of gestation in a pregnancy complicated by severe pre-eclampsia, resulting in neonatal death despite timely intervention.

Keywords : MCA Doppler, Reverse End-Diastolic Flow, Pre-eclampsia, Fetal Hypoxia.

References :

  1. Baschat AA, Gembruch U, Harman CR. The sequence of changes in Doppler and biophysical parameters as severe fetal growth restriction worsens. Ultrasound Obstet Gynecol. 2001.
  2. Moise KJ. The usefulness of middle cerebral artery Doppler assessment in the treatment of the fetus at risk for anemia. Am J Obstet Gynecol. 2008.
  3. Respondek M, Woch A, Kaczmarek P, Borowski D. Reversal of diastolic flow in the middle cerebral artery of the fetus. Ultrasound Obstet Gynecol. 2000.
  4. Nicholaides KH, Rizzo G, Hecher K. Doppler studies in fetal hypoxemia. The Fetal Medicine Foundation; 2002.
  5. Jakobovits AA. Reverse flow in the fetal middle cerebral artery. Am J Obstet Gynecol. 1997.
  6. Sepulveda W, Shennan AH, Peek MJ. Reverse end-diastolic flow in the middle cerebral artery: an agonal pattern. Am J Obstet Gynecol. 1996.
  7. Giancotti A, et al. Reverse end-diastolic flow in a fetus with liver malformation: case report. J Med Case Rep. 2011.
  8. Society for Maternal-Fetal Medicine. Doppler assessment in fetal growth restriction. Am J Obstet Gynecol. 2012.
  9. Chainarong N, Suwanrath C, Suksai M. Persistent reversed end-diastolic flow of the MCA: a rare finding. J Clin Ultrasound. 2022.
  10. Obeidat N, et al. MCA Doppler in congenital hydrocephalus. J Matern Fetal Neonatal Med. 2018.

Middle cerebral artery (MCA) Doppler assessment is an important tool in evaluating fetal well-being. Normally, the MCA demonstrates high-resistance flow, but in hypoxic states it becomes low resistance due to the brain-sparing effect. In advanced compromise, reverse end-diastolic flow (REDF) may occur, indicating severe pathology. Persistent MCA-REDF is rare and associated with poor fetal and neonatal outcomes. We report a case of persistent MCA-REDF at 30 weeks of gestation in a pregnancy complicated by severe pre-eclampsia, resulting in neonatal death despite timely intervention.

Keywords : MCA Doppler, Reverse End-Diastolic Flow, Pre-eclampsia, Fetal Hypoxia.

Paper Submission Last Date
31 - March - 2026

SUBMIT YOUR PAPER CALL FOR PAPERS
Video Explanation for Published paper

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.
Subscribe
OR

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.
Subscribe