Pharmacological Effects of the "Hydroxychloroquine-Azithromycin Combination” on the Hematological and Biochemical Parameters of Symptomatic COVID-19 Patients: Case of Amissa Bongo Regional Hospital Center of Franceville

Authors : Bourdettes Meye; Dieudonné Nkoghe; Robert Eya'ama Mve; Joseph Privat Ondo; Cédric Sima Obiang; Louis-Clément Obame Engonga

Volume/Issue : Volume 8 - 2023, Issue 7 - July

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Background: The end of 2019 was marked by the emergence of a new virus called SARS-CoV-2 responsible for COVID-19 (Corona Virus Disease - 2019). This viral disease, which took off in the People's Republic of China, rapidly mutated into a pandemic by March 2020. The therapeutic management of this new disease has been the subject of much speculation, given the absence of a vaccine. The high cure rate observed on Gabonese soil prompted the launch of this study. The objective of this study was to conduct a single-center retrospective observational study to assess the time to cure in symptomatic COVID-19 patients hospitalized at Amissa Bongo Regional Hospital Center of Franceville (CHRAB). Method: Between May 16 and August 31, 2020, the medical records of all patients suffering from Covid-19 and treated by the "national COVID-19 protocol" were collected. Viral diagnosis was performed by gene amplification on the Applied Biosystems AB 7500 Real Time PCR System, according to the SARS-CoV-2 diagnostic protocol validated by the Africa CDC and the African Union. Results: The speed of recovery was related to the presence or absence of comorbidity in treated patients. Liver damage marked by elevated serum transaminases was observed in these patients, due to heavy consumption of often-hepatotoxic drugs, while renal function was generally unaffected. Anemia is recurrent in these patients, and consequently increases their plasma bilirubin levels. Conclusion: This study shows that the 45 to 50 age group is the one most affected by the SARS CoV- 2 virus, and that women are 1.2 times more contaminated than men. Of all the reasons for consultation recorded, fever is the first symptom, followed by cough and dyspnea. The "Hydroxychloroquine-Azithromycin" combination is a therapeutic protocol adopted by many countries around the world. Its efficacy depends on the absence of comorbidity in treated patients. Most patients recover after 10 days of treatment.

Keywords : National Therapeutic Protocol, SARS-CoV-2, COVID-19, Amissa Bongo Regional Hospital Center.


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