Pharmacological Insights and Clinical Strategies in the Treatment of Iron and Vitamin B12 Deficiency Anemia


Authors : Saravanan Madhumitha; Murugavel Elakkkiya; Cathalin Salaman; Anandhavolu Sorna; Shafana Farveen; Momunava A.A.; Bhakhtierova M.B.

Volume/Issue : Volume 10 - 2025, Issue 10 - October


Google Scholar : https://tinyurl.com/325hkp8d

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DOI : https://doi.org/10.38124/ijisrt/25oct1233

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Abstract : Iron deficiency anemia (IDA) and vitamin B12 deficiency anemia are two of the most common types of nutritional anemia that affect people of all ages all over the world. Iron deficiency anemia and vitamin B12 deficiency anemia, if left and examined or untreated until late in the course, may result in fatigue, weakness, occasionally neurologic abnormalities. Early diagnosis and treatment must be made easy in order to ensure improved patient wellbeing and to prevent complications. The clinical and pharmacological treatment of Iron deficiency anemia and B12 deficiency anemia is presented in this article, with a focus on administration of different iron preparations like ionic(divalent) and non-ionic (trivalent). Vitamin B12 replacement therapy, administration, administration doses, and monitoring for safety and efficacy are presented. The aim is to offer evidence based recommendations for selecting the optimum treatment for a given patient.

Keywords : Iron Deficiency Anemia, Vitamin B12 Deficiency Anemia, Divalent and Trivalent Iron, Pharmacological Management, Treatment Safety and Effectiveness.

References :

  1. Alexander K.C. leung,  Joseph M. Lam, et Al. Iron deficiency anemia: An updated review. Current pediatr Rev. Aug,2023,20(3): P339-356. https://doi.org/10.2174/1573396320666230727102042
  2. Aditi Kumar, Esha Sharma, et Al. Iron deficiency anemia: pathophysiology, assessment, practical management. BMJ open Gastroenterol. Jan,2022,9(1): e000759. https://doi.org/10.1136/bmjgast-2021-000759
  3. Shikha Bathla, Shalini Arora. Prevalence and approaches to manage iron deficiency anemia (IDA). Crit Rev Food Sci Nutr. Jun,2021, 62(32): P8815-8828. https://doi.org/10.1080/10408398.2021.1935442
  4. Anthony Lopez, Prof Patrice Cacoub, et Al. Iron deficiency anemia. The Lancet. Feb, 2016,387(10021): P907-916. https://doi.org/10.1016/s0140-6736(15)60865-0
  5. Maria Domenica  cappellini,  Josep comin-colet, et Al. Iron deficiency across  chronic inflammatory conditions: International expert opinions on definition,  diagnosis, and management. Am J hematol. Jul,2017, 92(10): P1068-1078. https://doi.org/10.1002/ajh.24820
  6. Santiago Garcia-Lopez, Judith Millastre Bocos, et Al. High-dose intravenous treatment in iron deficiency anemia in Inflammatory bowel disease: Early efficacy and impact on quality of life. Blood Transfus. May,2016, 14(2): P199-205. https://doi.org/10.2450/2016.0246-15
  7. Kristine Michelle Jimenez, Christoph Gasche. Management of Iron deficiency anaemia in Inflammatory bowel disease.  Acta haematol. Apr,2019, 142(1): P32-36. https://doi.org/10.1159/000496728
  8. Christoph Gasche, Tariq Ahmad, et Al. Ferric Maltol Is Effective in Correcting Iron Deficiency Anemia in Patients with Inflammatory Bowel Disease: Results from a Phase-3 Clinical Trial Program. Inflammatory bowel disease. Mar, 2015, 21(3): P579-588. https://doi.org/10.1097/mib.0000000000000314
  9. Benjamin Elsrott, Lubna Khan, et Al. The role of iron depletion in adult iron deficiency anemia and other diseases. Eur J Haematol.  Mar,2020, 104(3): P153-161. https://doi.org/10.1111/ejh.13345
  10. Thomas G. DeLoughery, Christian S. Jackson, et Al. AGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review. Clin Gastroenterol Hepatol. Aug,2024, 22(8): P1575-1583. https://doi.org/10.1016/j.cgh.2024.03.046
  11. Jean – Louis Guéant, Rosa-Maria Guéant-Rodriguez, et Al. Vitamin B12 absorption and malabsorption. Vitamin Horm. Mar,2022, 119: P241-274. https://doi.org/10.1016/bs.vh.2022.01.016
  12. Ch S Pavlov, I V damulin, et Al. Neurological disorders in Vitamin B12 deficiency.  Ter Arkh. May,2019, 91(4): P122-129. https://doi.org/10.26442/00403660.2019.04.000116
  13. Alexander J Layden, Kristof Täse, et Al. Neglected tropical diseases and vitamin B12: A review of the current evidence. Trans R soc Trop Med Hyg. Oct,2018,112(10): P423-435. https://doi.org/10.1093/trstmh/try078
  14. Gabriele Röhrig, Ines Gütgemann, et Al. [Clinical hematological symptoms of vitamin B12 deficiency in old age : Summarized overview of this year’s symposium of the Working Group “Anemia in the Aged” on the occasion of the annual conference of the German Geriatric Society (DGG) in Frankfurt]. Z Gerontol Geriatr. Jun,2018, 51(4): P446-452. https://doi.org/10.1007/s00391-018-1410-z
  15. Robert C. Langan, Andrew J. Goodbred.  Vitamin B12 Deficiency: Recognition and management. Am fam physician. Sep,2017,96(6): P384-389. PMID: 28925645
  16. Robert C langan, Kimberly J Zawistoski. Update on Vitamin B12 deficiency. Am fam physician. Jun,2011,83(12): P1425-1430. PMID: 21671542

Iron deficiency anemia (IDA) and vitamin B12 deficiency anemia are two of the most common types of nutritional anemia that affect people of all ages all over the world. Iron deficiency anemia and vitamin B12 deficiency anemia, if left and examined or untreated until late in the course, may result in fatigue, weakness, occasionally neurologic abnormalities. Early diagnosis and treatment must be made easy in order to ensure improved patient wellbeing and to prevent complications. The clinical and pharmacological treatment of Iron deficiency anemia and B12 deficiency anemia is presented in this article, with a focus on administration of different iron preparations like ionic(divalent) and non-ionic (trivalent). Vitamin B12 replacement therapy, administration, administration doses, and monitoring for safety and efficacy are presented. The aim is to offer evidence based recommendations for selecting the optimum treatment for a given patient.

Keywords : Iron Deficiency Anemia, Vitamin B12 Deficiency Anemia, Divalent and Trivalent Iron, Pharmacological Management, Treatment Safety and Effectiveness.

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Paper Submission Last Date
31 - December - 2025

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