Authors : S. Hadiza; M. H. Shagal; M. F. Yahaya; B. Fatihat

Volume/Issue : Volume 11 - 2026, Issue 8 - August

Google Scholar : https://tinyurl.com/ju9fj64c

DOI : https://doi.org/10.38124/ijisrt/26aug1138

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Medicinal plants remain one of important sources of bioactive compounds for the discovery of therapeutic agents. This study investigated the phytochemical composition, antioxidant, antimicrobial, and anti-inflammatory activities of Vitex doniana and Detarium microcarpum extracts (stem bark and leaf). Plant sample was extracted with methanol usning soxhalet extractor. Phytochemical screening was carried out using standard method. Antioxidant activities was assessed using DPPH radical scavenging. Antimicrobial activities was evaluated using the agar wall diffusion method and anti-inflammatory activities was carried out using inhibition of albumin denaturation (in vitro). The study showed the presence of alkaloids, flavonoids, tannins, steroids, and glycosides on both the plant extracts.

Keywords : Antioxidant, Antimicrobial, Glycoside, Plant, Phytochemicals Vitex doniana.

References :

1. Adebayo, S. A., Dzoyem, J. P., Shai, L. J., & Eloff, J. N. (2019). The anti-inflammatory and antioxidant activity of selected medicinal plants used in South African traditional medicine. BMC Complementary Medicine and Therapies, 19, 176. https://doi.org/10.1186/s12906-019-2599-5
2. Adewale, O. B., Adekeye, A. O., Akintayo, C. O., Onikanni, S. A., & Sabiu, S. (2021). Evaluation of antioxidant and anti-inflammatory activities of medicinal plants used in Nigerian traditional medicine. Journal of Ethnopharmacology, 268, 113570. https://doi.org/10.1016/j.jep.2020.113570
3. Ahad, B., Shahri, W., Rasool, H., Reshi, Z. A., Rasool, S., & Hussain, T. (2021). Medicinal plants and herbal drugs: An overview. Medicinal and Aromatic Plants: Healthcare and Industrial Applications, 1–40.
4. Ajayi, A. M., Ologe, M. O., Ben-Azu, B., &Ademowo, O. G. (2018). Anti-inflammatory and analgesic activities of Detariummicrocarpum stem bark extract. Journal of Herbs, Spices & Medicinal Plants, 24(4), 356–369. https://doi.org/10.1080/10496475.2018.1488321
5. Auwal, M. S., Saka, S., Mairiga, I. A., Sanda, K. A., Shuaibu, A., & Ibrahim, A. (2020). Phytochemical properties and antioxidant activity of Detariummicrocarpum leaf extract. Journal of Medicinal Plants Research, 14(2), 77–84.
6. Burkill, H. M. (1997). The useful plants of West Tropical Africa (Vol. 4, 2nd ed.). Royal Botanic Gardens, Kew.
7. Darsini, P. A., Shamshad, S., & John, M. P. (2015). Canna indica (L.): A plant with potential healing power: A review. International Journal of Biological Science, 6(2), 1–8.
8. Dinarello, C. A. (2010). Anti-inflammatory agents: Present and future. Cell, 140(6), 935–950.
9. Egharevba, H. O., Kunle, O. F., Iliya, I., Etuk, E. U., Eboh, I. E., &Adefolalu, F. S. (2015). Phytochemical analysis and antimicrobial activity of Vitex donianaSweet leaves. African Journal of Biotechnology, 14(5), 441–446.
10. George, B. P., Chandran, R., &Abrahamse, H. (2021). Role of phytochemicals in cancer chemoprevention: Insights. Antioxidants, 10(9), 1455. https://doi.org/10.3390/antiox10091455
11. Kumar, R. S., Sivakumar, T., Sunderam, R. S., Gupta, M., Mazumddar, U. K., Gomathi, P., Rajeshwa, Y., Saravana, S., Kumar, M. S., Murugesh, K., & Kumar, K. A. (2005). Antioxidant and antimicrobial activities of Bauhinia racemosa L. stem bark. Brazilian Journal of Medical and Biological Research, 38, 1015–1024.
12. Leyva, C. M., Torres, L. R., Ortiz, S. R. L., Marsinyach, R. I., Navarro, M. L., Mangudo, P. A. B., &Ceano-Vivas, C. M. (2019). Positioning document of the Spanish Association of Pediatrics Group for the study of pediatric pain on the registration of pain as the fifth vital sign. Anales de Pediatría (English Edition), 91(1), 58.
13. Lockett, C. T., Calvert, C. C., & Grivetti, L. E. (2000). Energy and micronutrient composition of dietary and medicinal wild plants consumed during drought. Journal of Food Composition and Analysis, 13(4), 449–462.
14. Manson, S. C., Brown, R. E., Cerulli, A., & Vidaurre, C. F. (2009). The cumulative burden of oral corticosteroid side effects and the economic implications of steroid use. Respiratory Medicine, 103(7), 975–994.
15. Molyneux, P. (2004). The use of the stable free radical diphenylpicryl-hydrazyl (DPPH) for estimating antioxidant activity. Songklanakarin Journal of Science and Technology, 26(2), 211–219.
16. Oibiokpa, F. I., Adoga, G. I., Saidu, A. N., & Chiroma, S. M. (2014). Nutritional and anti-nutritional composition of Detariummicrocarpum fruits. African Journal of Food Science, 8(6), 345–350.
17. Onoja, S. O., Ezeja, M. I., Omeh, Y. N., & Onwukwe, B. C. (2017). Anti-inflammatory and analgesic activities of methanolic extract of Vitex doniana leaves. Journal of Medicinal Plants Research, 11(5), 92–98.
18. Payne R. 2000. Limitations of NSAIDs for pain management: Toxicity or lack of efficacy? The Journal of Pain 1 (3): 14–18.
19. Rahayu, Y. Y. S., Araki, T., &Rosleine, D. (2020). Factors affecting the use of herbal medicines in the universal health coverage system in Indonesia. Journal of Ethnopharmacology, 260, 112974.
20. Sies, H., Berndt, C., & Jones, D. P. (2017). Oxidative stress. Annual Review of Biochemistry, 86(1), 715–748.
21. Silhavy, T. J., Kahne, D., & Walker, S. (2010). The bacterial cell envelope. Cold Spring Harbor Perspectives in Biology, 2(5), a000414. https://doi.org/10.1101/cshperspect.a000414
22. Ullah, R., Alqahtani, A. S., Noman, O. M. A., Alqahtani, A. M., Ibenmoussa, S., &Bourhia, M. (2020). A review on ethno-medicinal plants used in traditional medicine in the Kingdom of Saudi Arabia. Saudi Journal of Biological Sciences, 27(10), 2706–2718.
23. World Health Organization. (2000). Quality control methods for medicinal plant materials (pp. 34–35). Geneva, Switzerland.
24. Zheng, Z., Zhang, L., & Hou, X. (2022). Potential roles and molecular mechanisms of phytochemicals against cancer. Food & Function, 13(18), 9208–9225. https://doi.org/10.1039/D2FO01208C.