Authors : Dr. Pramod Kumar Minocha; Dr. Deveshkumar Mahendralal Kothwala; Dikshita Yogendrashigh Lodha; Unnati Girish Patel; Mansi Samir Desai

Volume/Issue : Volume 9 - 2024, Issue 9 - September

Google Scholar : https://tinyurl.com/2s49s92u

Scribd : https://tinyurl.com/34dt6aby

DOI : https://doi.org/10.38124/ijisrt/IJISRT24SEP213

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Abstract : Antibiotic beads represent a compelling treatment method for the treatment and prevention of canine osteomyelitis, as they provide localized antibiotic concentrations at the infection site with minimal systemic toxicity. The therapeutic efficacy of these beads has been demonstrated, highlighting their potential as a valuable local antibiotic therapy. In particular, the introduction of vancomycin - polymethylmethacrylate (PMMA) beads is highlighted as a promising new form of local antibiotic therapy. This article focuses on the use of antibiotic-impregnated beads to treat localized bacterial infections in the bones and joints of canines. Typically composed of poly(lactic-co-glycolic acid) (PLGA) or polymethylmethacrylate (PMMA), these beads contain antibiotics such as vancomycin, placed directly into the affected area, providing a high antibiotic concentration at the site of infection. These beads were developed for a slow antibiotic release over time; they ensure a constant protective effect against a broad spectrum of bacteria, demonstrating high efficacy and biocompatibility with the animal's body. This localized antibiotic treatment option offers several advantages over systemic antibiotics, such as reduced side effects and improved efficacy. It could be a promising option for the treatment of bone and joint infections in canines.

Keywords : Canine Osteomyelitis, Antibiotic-Impregnated Beads, Vancomycin, PMMA, PLGA.

References :

1. Wahlig, H., Dingeldein, E., Bergmann, R., & Reuss, K. (1978). The release of gentamicin from polymethylmethacrylate beads. An experimental and pharmacokinetic study. The Journal of bone and joint surgery. British volume, 60-B(2), 270–275. https://doi.org/10.1302/0301-620X.60B2.659478
2. Cunningham, A., Demarest, G., Rosen, P., & DeCoster, T. A. (2000). Antibiotic bead production. The Iowa orthopaedic journal, 20, 31–35.
3. Gomes, D., Pereira, M., & Bettencourt, A. F. (2013). Osteomyelitis: an overview of antimicrobial therapy. Brazilian Journal of Pharmaceutical Sciences, 49, 13-27.
4. Olsen, R. S., Sawyere, D. M., Davis, J. L., Lanz, O. I., & Werre, S. R. (2023). Bead size has a greater effect on in vitro elution from antimicrobial-impregnated calcium sulfate beads than drug concentration. American journal of veterinary research, 84(5), ajvr.22.12.0216. https://doi.org/10.2460/ajvr.22.12.0216
5. Lindsay C. Peterson DVM, Stanley E. Kim BVSc, MS, DACVS, Daniel D. Lewis DVM, DACVS, Matthew D. Johnson DVM, MS, DACVS, Cassio R. A. Ferrigno DVM, PhD, MS First published: 25 January 2021 https://doi.org/10.1111/vsu.13570
6. Peterson, L. C., Kim, S. E., Lewis, D. D., Johnson, M. D., & Ferrigno, C. R. A. (2021). Calcium sulfate antibiotic-impregnated bead implantation for deep surgical site infection associated with orthopedic surgery in small animals. Veterinary surgery : VS, 50(4), 748–757. https://doi.org/10.1111/vsu.13570
7. FSeligson, D., Popham, J., Voos, K., Henry, S.L.,Paguri, M.: Antibiotic leaching from polymethylmethacrylate beads. J Bone Joint Surg, 75A(5): 714-720, 1993.
8. Henry, S.L., Ostermann, P.A.W., Seligson, D.: The prophylactic use of antibiotic impregnated beads in open fractures. J Trauma 30: 1231-1238, 1990.
9. Goodell, J.A., Flick, A.B., Hebert, J.C., and Howe, J.G.: Preparation and release characteristics of tobramycin impregnated polymethylmethacrylate beads. Am J Hosp Pharm, 43: 1454-1460, 1986.
10. LAMP, K.C.; FRIEDRICH, L.V.; MENDEZ-VIGO, L.; RUSSO, R. Clinical experience with daptomycin for the treatment of patients with osteomyelitis. Am. J. Med., v.120, n.10, suppl.1, p.S13-S20, 2007.
11. MARRA, F.; ROBBINS, G.M.; MASRI, B.A.; DUNCAN, C.; WASAN, K.M.; KWONG, E.H.; JEWESSON, P.J. Amphotericin B-loaded bone cement to treat osteomyelitis caused by Candida albicans. Can. J. Surg., v.44, n.5, p.383- 386, 2001.
12. KANELLAKOPOULOU, K.; GIAMARELLOS-BOURBOULIS, E.J. Carrier systems for the local delivery of antibiotics in bone infections. Drugs, v.59, n.6, p.1223- 1232, 2000.
13. AMBROSE, C.G.; CLYBURN, T.A.; LOUDEN, K.; JOSEPH, J.; WRIGHT, J.; GULATI, P.; GOGOLA, G.R.; MIKOS, A.G. Effective Treatment of osteomyelitis with biodegradable microspheres in a rabbit model. Clin. Orthop. Relat. Res., v.421, p.293-299, 2004.
14. Santschi EM, McGarvey L. In vitro elution of gentamicin from plaster of Paris beads. Vet Surg. 2003;32(2): 128–133. doi:10.1053/jvet.2003.50010
15. SHIRTLIFF, M.E.; CALHOUN, J.H.; MADER, J.T. Experimental osteomyelitis treatment with antibiotic-impregnated hydroxyapatite. Clin. Orthop. Relat. Res., v.401, p.239-247, 2002.
16. SAMUEL, S.; MATHEW, B.S.; VEERARAGHAVAN, B.; FLEMING, D.H.; SAMUEL, B.; CHITTARANJAN, S.B.; PRAKASH, J.A. In vitro study of elution kinetics and bio-activity of meropenem-loaded acrylic bone cement. J. Orthopaedics Traumatol., v.13, n.3, p.131-136, 2012.