Introduction: Distal pancreatectomy (DP) is a preferred therapy for pancreatic disorders that affect just the body and tail of the pancreas and do not include the head. Various methods are in practice for the stump closure after PD. The current study assesses the comparison of the autologous patch, hand sutured, and staple in terms of postoperative complications and hospital stays in stump closure after DP. Method: A prospective study was conducted in patients who underwent stump closure after DP between August 2017 and March 2022 at Hayatabad Medical Complex, Peshawar, Pakistan. After giving informed consent, the patient was divided into three groups, including the autologous patch group (APG), hand sutured group (HSG), and stapled group (SG). The outcome of the current study was operation time, intraoperative bleeding, POPF, and hospital stay. The statistical analysis was carried out using SPSS v25. Results: The mean operation time was observed lowest in the APG while highest in the SG. In the SG, most of the patients were fell in ASA grade ranged from I to III, while most of the APG patients were fell in ASA grade I. The patients with grade C POPF was high in the HSG, whereas the grade B POPF was high in the SG. Based on CDC, the grade V postoperative complications were high in the HSG and SG. The hospital stay was observed less in patients who underwent autologous patch surgery compared to HSG and SG. Conclusion: The current study highlighted that an autologous patch was superior to hand-sewn stump closure after DP in terms of the operation time, POPF, postoperative complications based on CDC, and hospital stay. Whereas the patients presented almost the same postoperative complications who underwent autologous patch and stapled stump closure.

Keywords : Distal pancreatectomy, stump closure, postoperative complications.