Periodontitis is an advanced disease of untreated gingivitis which results in the destruction of the periodontal tissue which includes the gingiva, alveolar bone and cementum which is characterized by pocket formation. Periodontitis can be treated by providing therapy with antibiotics and anti-inflammatory drugs. Honeycomb (Trigona Sp) contains flavonoids, phenolic acids and their esters, which act as anti-inflammatory agents. The purpose of this study was to prove that honeycomb gel (Trigona Sp) as an alternative material has an effect on changes in clinical conditions in periodontitis in Wistar rats.

Keywords : Honeycomb Gel (Trigona Sp), Inflammation, Periodontitis, Wistar Rats.