Authors :
Ayodeji Oluwaseun Faremi; Olanrewaju Sunday; Akinwale John Faniyi; Ayoade Babatunde Olanrewaju; Babatunde Joseph Abioye; Temitope Daniel Adeleke; Olawale Sunday Animasaun; Ogunjimi Temitope; Tolulope Adaran; Abeeb Babatunde Jamiu; Oladeji Moroof Gbadamosi; Oluwafemi Odola; Maroof Adebayo Alatise; Adedayo Adeyemi
Volume/Issue :
Volume 8 - 2023, Issue 11 - November
Google Scholar :
http://tinyurl.com/ye2aab5w
Scribd :
http://tinyurl.com/33hz5ube
DOI :
https://doi.org/10.5281/zenodo.10370908
Abstract :
Background:
Tuberculosis in children is a consequence of adult
TB, but it's often neglected. Understanding treatment
outcomes in children is crucial for designing effective
interventions.Aim:
This study is aimed at evaluating some predicting
factors associated with and responsible for successful
and unsuccessful treatment in the Ede town health
centers of the sub-district of Osun State, Nigeria.Methods:
This retrospective study involved analyzing
statistically reviewed TB records of patients aged 0–14
years that were reported and enrolled between April
2018 and July 2021 at selected health facilities in Ede
town, including the laboratory Gene Xpert site.Results:
Of the 102 enrollees, 24/102 were aged 0–4 years,
with the mortality ratio (MR) being 0.35% (95% CI
0.17–0.56), and 45/102 [MR]:0.26% (95% CI 0.13-0.36)
were aged 5–9 years. 33/102 [(MR): 0.46% (95% CI
0.21-0.76)] were aged 10–14 years. 52/102 (51%) had a
household contact, while 45% represented other contacts.
One-quarter of our total respondents were co-infected
with HIV, while 75.5% had extra-
pulmonary tuberculosis. The treatment failure rate
decreased with increasing age, with 0–4 years having the
worst treatment failure rate at 50% and 10–14
years having the highest treatment success rate at 60.6%
compared to the remaining age group. Respondents with
good drug adherence status had 100% treatment success,
which was statistically significant (p value < 0.01).Conclusion:
The study found that drug adherence status in
children aged 0–14 in Ede Health Centers, Osun, Nigeria,
is a major predictor of unsuccessful tuberculosis
treatments. Factors such as difficulty understanding
instructions, parental supervision, taste, formulation,side effects, developmental changes, and inconsistent
routines contribute to these outcomes.Recommendation:
To improve drug adherence in children, healthcare
providers, parents, and children should improve
education, communication, and technology use.
Collaboration between professionals, researchers, and
policymakers is essential for identifying barriers and
implementing evidence-based strategies.
Keywords :
Childhood Tuberculosis, HIV Co-Infection, Extra-Pulmonary Tuberculosis.
Background:
Tuberculosis in children is a consequence of adult
TB, but it's often neglected. Understanding treatment
outcomes in children is crucial for designing effective
interventions.Aim:
This study is aimed at evaluating some predicting
factors associated with and responsible for successful
and unsuccessful treatment in the Ede town health
centers of the sub-district of Osun State, Nigeria.Methods:
This retrospective study involved analyzing
statistically reviewed TB records of patients aged 0–14
years that were reported and enrolled between April
2018 and July 2021 at selected health facilities in Ede
town, including the laboratory Gene Xpert site.Results:
Of the 102 enrollees, 24/102 were aged 0–4 years,
with the mortality ratio (MR) being 0.35% (95% CI
0.17–0.56), and 45/102 [MR]:0.26% (95% CI 0.13-0.36)
were aged 5–9 years. 33/102 [(MR): 0.46% (95% CI
0.21-0.76)] were aged 10–14 years. 52/102 (51%) had a
household contact, while 45% represented other contacts.
One-quarter of our total respondents were co-infected
with HIV, while 75.5% had extra-
pulmonary tuberculosis. The treatment failure rate
decreased with increasing age, with 0–4 years having the
worst treatment failure rate at 50% and 10–14
years having the highest treatment success rate at 60.6%
compared to the remaining age group. Respondents with
good drug adherence status had 100% treatment success,
which was statistically significant (p value < 0.01).Conclusion:
The study found that drug adherence status in
children aged 0–14 in Ede Health Centers, Osun, Nigeria,
is a major predictor of unsuccessful tuberculosis
treatments. Factors such as difficulty understanding
instructions, parental supervision, taste, formulation,side effects, developmental changes, and inconsistent
routines contribute to these outcomes.Recommendation:
To improve drug adherence in children, healthcare
providers, parents, and children should improve
education, communication, and technology use.
Collaboration between professionals, researchers, and
policymakers is essential for identifying barriers and
implementing evidence-based strategies.
Keywords :
Childhood Tuberculosis, HIV Co-Infection, Extra-Pulmonary Tuberculosis.
