Authors :
Dr. Avinash Buche; Dr. Gauri Dank; Dr. Vaishali Khadke; Dr. Sandhya Bhattad
Volume/Issue :
Volume 7 - 2022, Issue 7 - July
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3w7Hsns
DOI :
https://doi.org/10.5281/zenodo.6997148
Abstract :
Autoimmune diseases are common in
reproductive age group. Pregnancy is known to alter the
disease course in many patients with autoimmune
diseases.The aim of this study is to assess the impact
of autoimmune connective tissue disorders and its
treatment on the outcomes of pregnancy. Methods: 15
antenatal patients with autoimmune connective tissue
diseases, comprising of Systemic Lupus Erythematosus
(SLE), antiphospholipid antibody syndrome (APS),
Undifferentiated Connective Tissue Diseases (UCTD),
Rheumatoid Arthritis(RA),Sjogren’s syndrome, systemic
sclerosis were analyzed with respect to their parity,
obstetric history, course during the pregnancy and
maternal and fetal outcomes.
Results. The primary autoimmune disease was Systemic
lupus erythematosus in 5 patients, 3 patients had
Rheumatoid arthritis, 2 patients had Systemic sclerosis, 3
patients had Undifferentiated connective tissue disease
and 1 patient each had sjogren’s syndrome and Primary
Antiphospholipid antibody syndrome. : 6 patients had
active underlying disease at the time of pregnancy. 2
patients had bad obstetric history. 2 had preterm induced
vaginal deliveries and 1had preterm LSCS.
Maternal complications of pre-eclampsia, eclampsia was
observed in 2 patients with SLE and APS Fetal growth
restriction was observed in 3 patients. Intrauterine death
was reported in 2 patients. 1 patient with severe Systemic
lupus erythematosus with Anti phospholipid antibody
syndrome expired at 26 weeks of gestation.
Conclusions: Patients with active underlying disease had
more adverse outcomes like maternal mortality, FGR,
Preterm delivery and still birth. Well controlled
underlying autoimmune disease improves the maternal
and fetal outcomes.
Keywords :
Autoimmune Diseases in Pregnancy, SLE In Pregnancy, Antiphospholipid Antibody Syndrome, Rheumatoid Arthritis In Pregnancy, Recurrent Pregnancy Loss.
Autoimmune diseases are common in
reproductive age group. Pregnancy is known to alter the
disease course in many patients with autoimmune
diseases.The aim of this study is to assess the impact
of autoimmune connective tissue disorders and its
treatment on the outcomes of pregnancy. Methods: 15
antenatal patients with autoimmune connective tissue
diseases, comprising of Systemic Lupus Erythematosus
(SLE), antiphospholipid antibody syndrome (APS),
Undifferentiated Connective Tissue Diseases (UCTD),
Rheumatoid Arthritis(RA),Sjogren’s syndrome, systemic
sclerosis were analyzed with respect to their parity,
obstetric history, course during the pregnancy and
maternal and fetal outcomes.
Results. The primary autoimmune disease was Systemic
lupus erythematosus in 5 patients, 3 patients had
Rheumatoid arthritis, 2 patients had Systemic sclerosis, 3
patients had Undifferentiated connective tissue disease
and 1 patient each had sjogren’s syndrome and Primary
Antiphospholipid antibody syndrome. : 6 patients had
active underlying disease at the time of pregnancy. 2
patients had bad obstetric history. 2 had preterm induced
vaginal deliveries and 1had preterm LSCS.
Maternal complications of pre-eclampsia, eclampsia was
observed in 2 patients with SLE and APS Fetal growth
restriction was observed in 3 patients. Intrauterine death
was reported in 2 patients. 1 patient with severe Systemic
lupus erythematosus with Anti phospholipid antibody
syndrome expired at 26 weeks of gestation.
Conclusions: Patients with active underlying disease had
more adverse outcomes like maternal mortality, FGR,
Preterm delivery and still birth. Well controlled
underlying autoimmune disease improves the maternal
and fetal outcomes.
Keywords :
Autoimmune Diseases in Pregnancy, SLE In Pregnancy, Antiphospholipid Antibody Syndrome, Rheumatoid Arthritis In Pregnancy, Recurrent Pregnancy Loss.