To validate Serum proteins and Quetelet’s index as predictors of postoperative complications in elective major surgeries in Tertiary care centre.  Objective:  By using serum proteins to predict the postoperative complications in elective major surgeries.  By calculating the Quetelet’s index/ BMI to predict the postoperative outcomes in elective major surgeries.  To assess the postoperative complications due to decrease in serum proteins and above and below average range of BMI  Methodology: From December 2019 to December 2021, this prospective observational study was carried out at the government Villupuram medical college's department of general surgery. Total 100 patients were included in the study. The study includes all patients above the age of 12 and those who have been admitted for any major elective surgery through the department of surgery. Children younger than 12 years old, patients with diabetes mellitus, chronic renal illness, icterus, severe anaemia less than 7 gm/dl, chronic liver disease, and patients receiving steroids or chemotherapy are all disqualified from participating in the study. On admission, the eligible adult patients will undergo screening for enrolment in the trial. Case details, including the history and clinical examination, were recorded. Anthropometry: Measurements of height and weight. Serum proteins (Albumin and Globulin) were estimated during the investigation. Case details, including the history and clinical examination, were recorded. Follow up was done and discharged from the hospital. The collected information was analysed by using SPSS 23.  Results: 100 patients in total were enrolled. There were 28 women and 72 men among these patients. Most incidents affected people between the ages of 40 and 59 (35 percent). Out of 100 cases, 13 were determined to be cancerous. Complications were present in 38 out of 100 patients.Among the 38 cases with complication, 28 were male and 10 were female. Most instances have BMIs that are within the normal range. But complications are more common in the overweight population. The majority of the individuals with serum albumin levels between 2.5 and 3.0 g/dl had complications (25 cases).  Conclusion: Many other preoperative patient parameters fall short when compared to serum albumin concentration in terms of predicting surgical outcomes. This affordable test should be used more frequently to identify malnutrition and the possibility of adverse surgical outcomes.

Keywords : Serum Albumin, BMI, Post Operative Complications, Tertiary Care Center.