Authors :
Ajay Yadav; Akash Shrivastav; Alok Kumar Singh; Aman Kumar; Amit Kumar; Dr. Jagdish Chandra Rathi; Dr. Anjita Singh; Rahul Sharma
Volume/Issue :
Volume 7 - 2022, Issue 11 - November
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3UDrpap
DOI :
https://doi.org/10.5281/zenodo.7407326
Abstract :
The objective of this study was to preparation
and development of Diclofenac loaded aloevera gel
nanoparticles for transdermal drug delivery system. The
application of CCD is a useful tool for optimizing DCloaded alovera gel nanoparticles prepared by the
emulsion solvent evaporation technique. The optimized
nanoparticles obtained displayed an average particle size
of 226.83 nm with a norrow polydispersity index (0.271),
an EE of 49.9 % and a slow and prolonged drug release
over a period of 24 hours. Ethylcellulose nanoparticles of
Diclofenac sodium can be of significant practical use for a
sustaining drug release and decreasing side effects.
Keywords :
Extrudability, Spreadability, Evaluation, Viscosity, Homogeneity.
The objective of this study was to preparation
and development of Diclofenac loaded aloevera gel
nanoparticles for transdermal drug delivery system. The
application of CCD is a useful tool for optimizing DCloaded alovera gel nanoparticles prepared by the
emulsion solvent evaporation technique. The optimized
nanoparticles obtained displayed an average particle size
of 226.83 nm with a norrow polydispersity index (0.271),
an EE of 49.9 % and a slow and prolonged drug release
over a period of 24 hours. Ethylcellulose nanoparticles of
Diclofenac sodium can be of significant practical use for a
sustaining drug release and decreasing side effects.
Keywords :
Extrudability, Spreadability, Evaluation, Viscosity, Homogeneity.
