Authors :
Adejo Peter O; Ajibade G. A; Muhamed Jamiu A.
Volume/Issue :
Volume 6 - 2021, Issue 11 - November
Google Scholar :
http://bitly.ws/gu88
Scribd :
https://bit.ly/3m6ulOu
Abstract :
In the last two decades, increase in multidrug
resistance (MDR) of nosocomial bacterial has become a
major health challenge worldwide. Enterobacteriaceae
are significant causes of serious infections, and many of
the clinical important members of this family are
becoming increasingly resistant to currently available
antibiotics. In this study, one hundred and thirteen nonrepeated multidrug resistant enterobacteriaceae were
collected from a tertiary hospital for the study and
screened for betalactamase production using penicillinphenol red reagent. E. coli (38), K. Pneumonae (20),
Shigellasp (24) and Salmonella sp (31) were the
organisms of interest. Results showed the isolates had a
MARI of 0.6 and 48.67% of isolates were betalactamase
producers. Isolates were observed to be resistant to
various antibiotics with Augmentin having the highest
mean resistance rate of 0.98, Ampiclox 0.84,
Perfloxacillin 0.82, Erythromycin 0.81, Zinacef 0.79,
Amoxicillin and Ofloxacillin 0.77, Septrin and Rocephin
0.75, Chloramphenicol 0.67, Ciprofloxacillin 0.59,
Gentamycin 0.56 and streptomycin 0.44. Multi drug
resistance in isolates were very high with isolates been
resistant to at least six antibiotics and this is linked with
the production of betalactamase which render
betalactam antibiotics infective. There is need for closer
monitoring of drug resistant trends and betalactamase
production in both clinical and community settings. This
will go a long way in reducing the spread of antibiotic
resistance.
In the last two decades, increase in multidrug
resistance (MDR) of nosocomial bacterial has become a
major health challenge worldwide. Enterobacteriaceae
are significant causes of serious infections, and many of
the clinical important members of this family are
becoming increasingly resistant to currently available
antibiotics. In this study, one hundred and thirteen nonrepeated multidrug resistant enterobacteriaceae were
collected from a tertiary hospital for the study and
screened for betalactamase production using penicillinphenol red reagent. E. coli (38), K. Pneumonae (20),
Shigellasp (24) and Salmonella sp (31) were the
organisms of interest. Results showed the isolates had a
MARI of 0.6 and 48.67% of isolates were betalactamase
producers. Isolates were observed to be resistant to
various antibiotics with Augmentin having the highest
mean resistance rate of 0.98, Ampiclox 0.84,
Perfloxacillin 0.82, Erythromycin 0.81, Zinacef 0.79,
Amoxicillin and Ofloxacillin 0.77, Septrin and Rocephin
0.75, Chloramphenicol 0.67, Ciprofloxacillin 0.59,
Gentamycin 0.56 and streptomycin 0.44. Multi drug
resistance in isolates were very high with isolates been
resistant to at least six antibiotics and this is linked with
the production of betalactamase which render
betalactam antibiotics infective. There is need for closer
monitoring of drug resistant trends and betalactamase
production in both clinical and community settings. This
will go a long way in reducing the spread of antibiotic
resistance.
