Protective Role of Psidium guajava L. Leaf Extract in Preventing Diabetes Induced Oxidative Stress in Pancreas of Albino Rats

Authors : Sowmya BH; Usha Anandhi D

Volume/Issue : Volume 5 - 2020, Issue 11 - November

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The purpose of the current study is to evaluate the efficacy of Psidium guajava L. (PG) leaf extract in preventing diabetes-induced oxidative stress in male albino rats. Induction of Streptozotocin (STZ) resulted in a significant elevation in lipid peroxidation in the pancreas of rats. In contrast, the activity of superoxide dismutase, catalase, and reduced glutathione activities were significantly reduced in STZ induced diabetic rats compared to controls. However, supplementation with 250mg/kg/b.w of leaf extract of PG for eight weeks, significantly prevented the above alterations. In contrast, 500 mg/kg/b.w of leaf extract of PG could not prevent the STZ induced alterations in antioxidant enzyme activities in diabetic rats. These results clearly suggest the lower dose of PG leaf extract is potent enough to prevent oxidative stress in diabetic male rats.

Keywords : Psidium guajava L., Streptozotocin, Lipid peroxidation, Catalase.


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