Psoriasis is a persistent, genetically
influenced, relapsing, scaly, and inflammatory skin
condition. It is an autoimmune, chronic inflammatory
disease with a significant genetic component and an
unknown etiology that is characterized by inflammation
carried on by immune system failure. It is differentiated
by continuous inflammation, which causes
uncontrollable keratinocyte differentiation and
proliferation. Around the world, 125 million people
suffer from psoriasis, or between 1% and 3% of people
worldwide. Psoriasis is thought to impact 60 million
individuals worldwide, with 1.52% of the population in
the UK being affected. Psoriasis is a chronic skin
condition with a wide range of clinical manifestations,
including plaque, flexural, guttate, pustular, and
erythrodermic lesions. Plaque psoriasis is the most
typical form of psoriasis; however, the illness is clinically
heterogeneous in its symptoms and natural history
depending on the patient's age, the environment in which
they live, and the locations that are afflicted. Psoriatic
arthritis, palmoplantar pustulosis, and generalized
pustular psoriasis are three distinct but related
phenotypes. For the treatment of mild to severe
psoriasis, topical treatments such corticosteroids,
vitamin D analogues, and tazarotene are effective.
Treatment options for psoriasis include topical
medications (corticosteroids and vitamin D analogues),
phototherapy (psoralen and ultraviolet A radiation),
basic systemic medications (methotrexate, cyclosporin,
and acitretin), biological agents (TNF tumor necrosis
factor, interleukin IL-17 and IL-23 inhibitors), and small
molecules inhibitor therapies. Numerous comorbidities,
such as depression, lymphoma, and cardiovascular
disease, are linked to psoriasis. Although psoriasis
cannot presently be cured, care should attempt to
minimize physical and psychological suffering by
treating patients early in the disease process, recognizing
and avoiding related multimorbidity, instilling lifestyle
improvements, and adopting a personalized approach to
treatment.
Keywords : Autoimmune, keratinocyte, Erythrodermic Lesions, Plaque Psoriasis, Palmoplantar Pustulosis, Multimorbidity.