The present study was done to compare the quality of life among patients who have undergone PTCA and CABG. The objectives of the study were, to assess the quality of life of patients who have undergone PTCA, to assess the quality of life of patients who have undergone CABG, to compare the quality of life of patients who have undergone PTCA and CABG, find out the association between quality of life scores of patients who have undergone PTCA and CABG with the selected demographic and clinical variables. The sample consisted of 100 patients, 50 patients who have undergone PTCA and 50 patients who have undergone CABG who were selected by purposive sampling technique. The design used was descriptive research design with quantitative approach. The tools used were Structured Questionnaire on socio demographic and clinical data and WHOQOLBREF questionnaire to assess the quality of life. The data was analysed using descriptive and inferential statistics. The findings of the study depicted that 44% of samples who have undergone PTCA and 66% of samples who have undergone CABG had good quality of life. The study findings revealed that there was significant difference (t =2.336, p=0.02) in the quality of life among patients who have undergone PTCA and CABG. The study concluded that patients who have undergone CABG have overall good quality of life than that of patients who have undergone PTCA. The study findings showed that there was significant association between quality of life of patients who have undergone PTCA and level of education (Fishers exact significance= 0.015), ejection fraction (Fishers exact significance= 0.013), and history of hospitalization due to cardiac cause (Fishers exact significance= 0.014). The study findings revealed that there was significant association between quality of life of patients who have undergone CABG