Authors : Dr. Dhwani Patel; Hajer Adam; Nathaly Toribio; Gabriela Gonzalez

Volume/Issue : Volume 10 - 2025, Issue 9 - September

Google Scholar : https://tinyurl.com/4y3p2sze

Scribd : https://tinyurl.com/bd74t9zh

DOI : https://doi.org/10.38124/ijisrt/25sep1019

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Note : Google Scholar may take 30 to 40 days to display the article.

Abstract : Regenerative dentistry is changing the game in oral healthcare. Instead of just fixing problems with artificial materials, we're now learning how to help teeth and gums heal themselves using the body's natural repair systems. This review explored how stem cells from different parts of the mouth like dental pulp, baby teeth, and the tissues around teeth can actually regrow damaged structures. We're talking about regrowing the inside of teeth, the supporting ligaments, and even the hard outer layers. What makes this possible is the combination of these powerful stem cells with smart biomaterials and cutting-edge 3D printing technology. Think of it as giving the body the right tools and instructions to fix itself. Major dental schools across the U.S., including Penn, UCSF, Michigan, Columbia, and Colorado, are leading this research revolution. Their work is bringing us closer to treatments that are less invasive, more natural, and long lasting than anything we've had before.

Keywords : Biomaterials, Regeneratice Dentistry, 3D BioPrinitng, Tissue Regrow, Biology/Stem Cells.

References :

1. Andrew I. Spielman. "Dental education and practice: past, present, and future trends." Frontiers in Oral Health, 17 Apr. 2024, https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2024.1368121/full
2. "Emerging Trends and Innovations Shaping the Dental Industry." Ameritas, 29 May 2025, https://www.ameritas.com/insights/emerging-trends-and-innovations-shaping-the-dental-industry/
3. "Dentists as Innovators: Exploring Their Contributions to Biomedical Advances." Cornerstone Smiles, 16 Jan. 2025, https://cornerstonesmiles.com/dentists-as-innovators-exploring-their-contributions-to-biomedical-advances/
4. "The Future of Dentistry: Technology Innovations in 2025." HR for Health, 22 Feb. 2024, https://hrforhealth.com/blog/the-future-of-dentistry-technology-innovations-in-2025
5. Sarah Lee. "Ultimate Guide: Personalized Dentistry & Evidence-Based Practice." Number Analytics, 15 Jun. 2025, https://www.numberanalytics.com/blog/ultimate-guide-personalized-dentistry-evidence-based
6. Paczkowska-Walendowska, Magdalena, Maciej Kulawik, Jakub Kwiatek, Dimitrios Bikiaris, and Judyta Cielecka-Piontek. "Novel Applications of Natural Biomaterials in Dentistry—Properties, Uses, and Development Perspectives" 5 May 2025 Materials 18, no. 9: 2124. https://doi.org/10.3390/ma18092124
7. "Research." University of Colorado School of Dental Medicine, https://dental.cuanschutz.edu/research
8. "Research." Columbia University College of Dental Medicine, https://www.dental.columbia.edu/research
9. "Preventive and Restorative Dental Sciences." UCSF School of Dentistry, https://dentistry.ucsf.edu/about/academic-departments/prds
10. Ragimova N, Abdullayev V, Mirzoyeva A, Mirzoyeva E. Application of Artificial Intelligence in Dentistry. Health Leadership and Quality of Life. 2024; 3:.454. https://doi.org/10.56294/hl2024.454
11. "OMFS Research." UCSF School of Dentistry, https://dentistry.ucsf.edu/programs/post-grad/omfs/research
12. "Top Latest Dental Technologies and Innovations in Dentistry." Windham Family Dentistry, https://windhamdentist.com/latest-dental-technologies/
13. Agarwal, Sumeet et al. “Pioneering the Future of Oral Healthcare: Bioprinting and Its Transformative Clinical Potential in Dentistry.” Cureus vol. 17,2 e79030. 15 Feb. 2025, doi:10.7759/cureus.79030
14. "Advances in Digital Implantology." Pankey Institute, https://pankey.org/advances-in-digital-implantology/
15. "Our Labs." University of Michigan School of Dentistry, https://dent.umich.edu/research/our-labs
16. "Dental Stem Cells in Regenerative Dentistry: A Narrative Review of Therapeutic Strategies and Biomaterials." JCC Practice, https://jccpractice.com/article/dental-stem-cells-in-regenerative-dentistry-a-narrative-review-of-therapeutic-strategies-and-biomaterials-1042/
17. "Regenerative Dentistry Advances: The Future of Healing Teeth and Beyond." Grand Lake Dental, 15 Apr. 2025, https://www.grandlakedental.com/blog/2025/4/15/regenerative-dentistry-advances-the-future-of-healing-teeth-and-beyond/
18. "Research Overview." University of Pennsylvania School of Dental Medicine, https://www.dental.upenn.edu/research/research-overview/
19. "Dental Stem Cells in Regenerative Dentistry: A Narrative Review of Therapeutic Strategies and Biomaterials." JCC Practice, https://jccpractice.com/article/dental-stem-cells-in-regenerative-dentistry-a-narrative-review-of-therapeutic-strategies-and-biomaterials-1042/
20. Kołodziejska, Barbara et al. “Biologically Inspired Collagen/Apatite Composite Biomaterials for Potential Use in Bone Tissue Regeneration-A Review.” Materials (Basel, Switzerland) vol. 13,7 1748. 9 Apr. 2020, doi:10.3390/ma13071748
21. Yuan, Zhenglin et al. “Biomaterial selection for tooth regeneration.” Tissue engineering. Part B, Reviews vol. 17,5 (2011): 373-88. doi:10.1089/ten.TEB.2011.0041
22. "Ultimate Guide: Clinical Trials & Biomaterials in Dental Applications." Number Analytics, https://www.numberanalytics.com/blog/ultimate-guide-clinical-trials-biomaterials-dental-applications
23. Dong, Chanjuan, and Yonggang Lv. “Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives.” Polymers vol. 8,2 42. 4 Feb. 2016, doi:10.3390/polym8020042
24. Kotteda, Anil Kumar et al. “Advancements in Biodegradable Orthopaedic Implants: A Literature Review.” Indian journal of orthopaedics vol. 59,8 1090-1100. 22 Jun. 2025, doi:10.1007/s43465-025-01445-y
25. Rossi, Arianna et al. “Biomaterials for extrusion-based bioprinting and biomedical applications.” Frontiers in bioengineering and biotechnology vol. 12 1393641. 21 Jun. 2024, doi:10.3389/fbioe.2024.1393641
26. "The Future of Teledentistry in 2024: 3 Trends and Possibilities." The Teledentists, https://www.theteledentists.com/post/the-future-of-teledentistry-in-2024-3-trends-and-possibilities
27. Omigbodun, Francis T, and Bankole I Oladapo. “AI-Optimized Lattice Structures for Biomechanics Scaffold Design.” Biomimetics (Basel, Switzerland) vol. 10,2 88. 1 Feb. 2025, doi:10.3390/biomimetics10020088