Leprosy poses a very complex problem not only from a medical point of view but extends to social, economic and cultural problems. Based on initial observations in the working area of the Kampung Laut Health Center, 1 case was obtained in February 2021, and also from the results of initial interviews with 6 respondents and the survey results showed that most of the community still showed poor personal hygiene for leprosy prevention in the Puskesmas working area. the sea village of the east tanjung jabung district. This study aims to determine the relationship between knowledge and personal hygiene with the incidence of leprosy. This research is descriptive analytic using a Case Control approach. The results of this study show

Keywords : Knowledge, Personal Hygiene, Leprosy