This research includes the synthesis of silver/copper nanoparticles that were utilized to extract methyl orange (MO) from aqueous solutions using Antigonon Leptopus leaf extract. This method offers various benefits, including affordability, simplicity, the use of less harmful materials, and—most importantly— ecological friendliness. The synthesis of Silver/Copper nanoparticles using leaf extract has the requisite quality and is a simple, affordable process. The reduction reaction was examined by examining the color change after two to three hours after the leaf extract was combined with a solution of Silver Nitrate/Copper Sulphate and heated to a temperature of 60°C or 80°C. The variables (time, dosage, pH, concentration, and temperature) were correlated with the decolorization of Methyl Orange (MO) from aqueous solution using equilibrium experiments. The results obtained showed that the optimum conditions for the removal of Methyl Orange (MO) by using silver nanoparticles and leaf dust mixture were contact time of 105 min, dosage 1.75g, pH – 4, concentration – 40 ppm and temperature – 50oC which resulted in 84.62% dye removal from aqueous solution. And for Copper nanoparticles and leaf dust mixture were contact time of 90 min, dosage 2g, pH – 3 , concentration – 40ppm and temperature –50oC which resulted in 89.24% dye removal from aqueous solution. Thus, the copper nanoparticles seem to be a good adsorbent than silver nanoparticles for the decolorization of Methyl Orange dye from effluent wastewater. The Van't Hoff equation is used to analyze the adsorption process thermodynamically and to estimate the thermodynamic equilibrium constant (Kc). Changes in enthalpy (ΔH°), Gibbs free energy (ΔG°), and entropy (ΔS°) are determined from the value of (Kc). If ΔG° is negative, the adsorption is spontaneous. Entropy changes that are positive (ΔS° > 0) imply that the processes are possible and irreversible.