Background: The distinguishing features of neurodegenerative disorders include the death of neurons in the brain or spinal cord that, over time, results in the loss of a particular neuronal subtype or indiscriminate loss of neuronal populations, consequently Alzheimer’s and Huntington's diseases are said to cause the loss of neurons, while Parkinson's disease specifically and insufficiently damages dopaminergic neurons in the substantia nigra..Aims: In this study, inducers are used inside in vitro examinations of neuroblastoma cells as well as a fresh, contemporary nanobiotechnological approach to disease therapy.Method: The materials' cytotoxicity was evaluated using the MTT colorimetric test technique with minor modifications.The concentration ranges for the test samples were 160, 120, 80, 40, 200, μg/ml were added to a confluent monolayer plate containing the cell lines that had been cultured for 24 hours. The supernatant was collected after 72 hours of incubation at 37°C in a 5% CO2 incubator, and 25 μl of MTT reagent (2 mg/ml) was added to each well.Result: The cell lines SH-S5Y5. After 24 hours of treatment, cells were suspended and adherent, undifferentiated neuroblastoma cells, while cells after being induced with IC50 concentration of glyceraldehyde, Blebbing cells are a sign of early apoptosis. Cell after dopamine IC50 concentration induction. very few circularized cells. Cells were beginning to differentiate, Cell after treatment with IC50 concentrations of dopamine and Encapsulation Nano Curcumin. Absence of any circularized cell indicating all cells are adhered.Conclusion: This work highlighted the possibility that Encapsulated Nano Curcumin might be a potent therapeutic agent, especially for the treatment ofneurodegenerative diseases like Parkinson's Disease. However, more pre-clinical and clinical research is still required.

Keywords : Encapsulated Nano Curcumi, Neurodegenerative diseases and Sh-Sy-5y Cell Line.