Diabetes is a condition that impairs the body's ability to process blood glucose. Type 2 diabetes has several causes- genetics and lifestyle are the most important ones. A combination of these factors can cause insulin resistance, when your body doesn't use insulin as well as it should. Insulin resistance is the most common cause of type 2 diabetes. Alcohol abuse is said to influence several changes in the cytokine levels. The present study was undertaken to evaluate the role of cytokines, which seems to be the probable cause of insulin resistance leading to type 2 diabetes. 400 subjects were included in the study divided into Control (Group I) 100 non-alcoholic control, 100 alcoholic healthy controls. Diabetic subjects as Group II- 100 newly diagnosed non- alcoholic diabetic patients and 100 newly diagnosed alcoholic diabetic patients respectively, both from the age group of 35-55 years. The result specified that there is a strong relation between increased cytokines levels due to alcohol abuse, insulin resistance and diabetic progression and its complication.

Keywords : Diabetes Mellitus, Interleukins, Cytokines, Alcohol, IL1, IL-6, IL-8, IL-10