Authors : Badal Tanwar; Dr. Ashutosh Upadhayay; Neha Sorout; Nitu

Volume/Issue : Volume 11 - 2026, Issue 4 - April

Google Scholar : https://tinyurl.com/245xbkne

Scribd : https://tinyurl.com/mvssdp25

DOI : https://doi.org/10.38124/ijisrt/26apr1638

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Parkinson’s disease (PD) is a progressive neurological disorder that mainly affects movement due to the gradual loss of dopamine-producing neurons in the brain. People with PD commonly experience tremors, muscle stiffness, slow movement and balance problems, along with non-motor symptoms such as sleep disturbances and mood changes. Although current medications like levodopa can relieve symptoms, they do not prevent the disease from progressing and may cause side effects over time. Therefore, researchers are increasingly interested in natural plant-based therapies that may protect nerve cells and slow disease development. Withania somnifera (Ashwagandha) and Greater Cardamom (Amomum subulatum) are traditional medicinal plants known for strong antioxidant and anti-inflammatory properties. Experimental studies suggest that Withania somnifera supports the survival of dopaminergic neurons by reducing oxidative stress, improving mitochondrial function and preventing cell damage. Similarly, Greater Cardamom has been shown to enhance dopamine levels, reduce brain inflammation and improve motor performance in animal models of PD. These findings indicate that both plants may offer potential neuroprotective benefits and could be used as supportive therapy for Parkinson’s disease.

Keywords : Parkinson’s Disease; Neurodegeneration; Withania Somnifera; Ashwagandha; Greater Cardamom; Amomum Subulatum; Neuroprotection; Dopaminergic Neurons; Oxidative Stress; Antioxidant Activity; Neuroinflammation; Herbal Therapy; Phytomedicine.

References :

1. Abdullah,  null, Ahmad, N., Tian, W., Zengliu, S., Zou, Y., Farooq, S., Huang, Q., & Xiao, J. (2022a). Recent advances in the extraction, chemical composition, therapeutic potential, and delivery of cardamom phytochemicals. Frontiers in Nutrition, 9, 1024820. https://doi.org/10.3389/fnut.2022.1024820
2. Abdullah, Ahmad, N., Tian, W., Zengliu, S., Zou, Y., Farooq, S., Huang, Q., & Xiao, J. (2022b). Recent advances in the extraction, chemical composition, therapeutic potential, and delivery of cardamom phytochemicals. Frontiers in Nutrition, 9, 1024820. https://doi.org/10.3389/fnut.2022.1024820
3. Abolarin, P. O., Amin, A., Nafiu, A. B., Ogundele, O. M., & Owoyele, B. V. (2024a). Optimization of Parkinson’s disease therapy with plant extracts and nutrition’s evolving roles. IBRO Neuroscience Reports, 17, 1–12. https://doi.org/10.1016/j.ibneur.2024.05.011
4. Abolarin, P. O., Amin, A., Nafiu, A. B., Ogundele, O. M., & Owoyele, B. V. (2024b). Optimization of Parkinson’s disease therapy with plant extracts and nutrition’s evolving roles. IBRO Neuroscience Reports, 17, 1–12. https://doi.org/10.1016/j.ibneur.2024.05.011
5. Acharya, R. (2024). The science and strategy of Ayurveda combination therapy: Opportunities, challenges, and future directions. Journal of Research in Ayurvedic Sciences, 8(6), 267–271. https://doi.org/10.4103/jras.jras_46_25
6. Afewerky, H. K., Ayodeji, A. E., Tiamiyu, B. B., Orege, J. I., Okeke, E. S., Oyejobi, A. O., Bate, P. N. N., & Adeyemi, S. B. (2021). Critical review of the Withania somnifera (L.) Dunal: Ethnobotany, pharmacological efficacy, and commercialization significance in Africa. Bulletin of the National Research Centre, 45(1), 176. https://doi.org/10.1186/s42269-021-00635-6
7. Aghasi, M., Koohdani, F., Qorbani, M., Nasli‐Esfahani, E., Ghazi‐Zahedi, S., Khoshamal, H., Keshavarz, A., & Sotoudeh, G. (2019). Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: A randomized double‐blind placebo controlled clinical trial. Journal of the Science of Food and Agriculture, 99(8), 3933–3940. https://doi.org/10.1002/jsfa.9617
8. Agnihotri, S., & Wakode, S. (2010). Antimicrobial activity of essential oil and various extracts of fruits of greater cardamom. Indian Journal of Pharmaceutical Sciences, 72(5), 657. https://doi.org/10.4103/0250-474X.78542
9. Alam, A., & Singh, V. (2021a). Composition and pharmacological activity of essential oils from two imported Amomum subulatum fruit samples. Journal of Taibah University Medical Sciences, 16(2), 231–239. https://doi.org/10.1016/j.jtumed.2020.10.007
10. Alam, A., & Singh, V. (2021b). Composition and pharmacological activity of essential oils from two imported Amomum subulatum fruit samples. Journal of Taibah University Medical Sciences, 16(2), 231–239. https://doi.org/10.1016/j.jtumed.2020.10.007
11. Alanazi, H. H., & Elfaki, E. (2023). The immunomodulatory role of withania somnifera (L.) dunal in inflammatory diseases. Frontiers in Pharmacology, 14, 1084757. https://doi.org/10.3389/fphar.2023.1084757
12. Ali, S., Noreen, A., Qamar, A., Zafar, I., Ain, Q., Nafidi, H.-A., Bin Jardan, Y. A., Bourhia, M., Rashid, S., & Sharma, R. (2023). Amomum subulatum: A treasure trove of anti-cancer compounds targeting TP53 protein using in vitro and in silico techniques. Frontiers in Chemistry, 11, 1174363. https://doi.org/10.3389/fchem.2023.1174363
13. Alruhaili, M. H., Almuhayawi, M. S., Gattan, H. S., Alharbi, M. T., Nagshabandi, M. K., Jaouni, S. K. A., Selim, S., & AbdElgawad, H. (2023a). Insight into the phytochemical profile and antimicrobial activities of Amomum subulatum and Amomum xanthioides: An in vitro and in silico study. Frontiers in Plant Science, 14, 1136961. https://doi.org/10.3389/fpls.2023.1136961
14. Alruhaili, M. H., Almuhayawi, M. S., Gattan, H. S., Alharbi, M. T., Nagshabandi, M. K., Jaouni, S. K. A., Selim, S., & AbdElgawad, H. (2023b). Insight into the phytochemical profile and antimicrobial activities of Amomum subulatum and Amomum xanthioides: An in vitro and in silico study. Frontiers in Plant Science, 14, 1136961. https://doi.org/10.3389/fpls.2023.1136961
15. Alruhaili, M. H., Almuhayawi, M. S., Gattan, H. S., Alharbi, M. T., Nagshabandi, M. K., Jaouni, S. K. A., Selim, S., & AbdElgawad, H. (2023c). Insight into the phytochemical profile and antimicrobial activities of Amomum subulatum and Amomum xanthioides: An in vitro and in silico study. Frontiers in Plant Science, 14, 1136961. https://doi.org/10.3389/fpls.2023.1136961
16. Aryal, S., Skinner, T., Bridges, B., & Weber, J. T. (2020). The Pathology of Parkinson’s Disease and Potential Benefit of Dietary Polyphenols. Molecules (Basel, Switzerland), 25(19), 4382. https://doi.org/10.3390/molecules25194382
17. Auti, S. T., & Kulkarni, Y. A. (2019a). Neuroprotective Effect of Cardamom Oil Against Aluminum Induced Neurotoxicity in Rats. Frontiers in Neurology, 10, 399. https://doi.org/10.3389/fneur.2019.00399
18. Auti, S. T., & Kulkarni, Y. A. (2019b). Neuroprotective Effect of Cardamom Oil Against Aluminum Induced Neurotoxicity in Rats. Frontiers in Neurology, 10, 399. https://doi.org/10.3389/fneur.2019.00399
19. Barani, M., Sangiovanni, E., Angarano, M., Rajizadeh, M. A., Mehrabani, M., Piazza, S., Gangadharappa, H. V., Pardakhty, A., Mehrbani, M., Dell’Agli, M., & Nematollahi, M. H. (2021a). Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature. International Journal of Nanomedicine, Volume 16, 6983–7022. https://doi.org/10.2147/IJN.S318416
20. Barani, M., Sangiovanni, E., Angarano, M., Rajizadeh, M. A., Mehrabani, M., Piazza, S., Gangadharappa, H. V., Pardakhty, A., Mehrbani, M., Dell’Agli, M., & Nematollahi, M. H. (2021b). Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature. International Journal of Nanomedicine, Volume 16, 6983–7022. https://doi.org/10.2147/IJN.S318416
21. Bashir, A., Nabi, M., Tabassum, N., Afzal, S., & Ayoub, M. (2023a). An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha). Frontiers in Pharmacology, 14, 1049334. https://doi.org/10.3389/fphar.2023.1049334
22. Bashir, A., Nabi, M., Tabassum, N., Afzal, S., & Ayoub, M. (2023b). An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha). Frontiers in Pharmacology, 14, 1049334. https://doi.org/10.3389/fphar.2023.1049334
23. Bashir, A., Nabi, M., Tabassum, N., Afzal, S., & Ayoub, M. (2023c). An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha). Frontiers in Pharmacology, 14, 1049334. https://doi.org/10.3389/fphar.2023.1049334
24. Bashir, A., Nabi, M., Tabassum, N., Afzal, S., & Ayoub, M. (2023d). An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha). Frontiers in Pharmacology, 14, 1049334. https://doi.org/10.3389/fphar.2023.1049334
25. Bashir, A., Nabi, M., Tabassum, N., Afzal, S., & Ayoub, M. (2023e). An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha). Frontiers in Pharmacology, 14, 1049334. https://doi.org/10.3389/fphar.2023.1049334
26. Bhargavi, S., & Madhan Shankar, S. R. (2021a). Dual herbal combination of Withania somnifera and five Rasayana herbs: A phytochemical, antioxidant, and chemometric profiling. Journal of Ayurveda and Integrative Medicine, 12(2), 283–293. https://doi.org/10.1016/j.jaim.2020.10.001
27. Bhargavi, S., & Madhan Shankar, S. R. (2021b). Dual herbal combination of Withania somnifera and five Rasayana herbs: A phytochemical, antioxidant, and chemometric profiling. Journal of Ayurveda and Integrative Medicine, 12(2), 283–293. https://doi.org/10.1016/j.jaim.2020.10.001
28. Chen, M.-C., Hsu, L.-L., Wang, S.-F., Pan, Y.-L., Lo, J.-F., Yeh, T.-S., Tseng, L.-M., & Lee, H.-C. (2021). Salubrinal Enhances Cancer Cell Death during Glucose Deprivation through the Upregulation of xCT and Mitochondrial Oxidative Stress. Biomedicines, 9(9), 1101. https://doi.org/10.3390/biomedicines9091101
29. Chen, R., Berardelli, A., Bhattacharya, A., Bologna, M., Chen, K.-H. S., Fasano, A., Helmich, R. C., Hutchison, W. D., Kamble, N., Kühn, A. A., Macerollo, A., Neumann, W.-J., Pal, P. K., Paparella, G., Suppa, A., & Udupa, K. (2022). Clinical neurophysiology of Parkinson’s disease and parkinsonism. Clinical Neurophysiology Practice, 7, 201–227. https://doi.org/10.1016/j.cnp.2022.06.002
30. Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam- 603103, Tamilnadu, India, & Krishnan, M. (2023). Anti oxidative/neuro-inflammation properties of Withania somnifera root extract on rotenone induced stress in rat brain. Bioinformation, 19(6), 729–738. https://doi.org/10.6026/97320630019729
31. Chinembiri, T., Gerber, M., Du Plessis, L., Du Preez, J., Hamman, J., & Du Plessis, J. (2017). Topical delivery of Withania somnifera crude extracts in niosomes and solid lipid nanoparticles. Pharmacognosy Magazine, 13(51), 663. https://doi.org/10.4103/pm.pm_489_16
32. Delgadillo-Puga, C., Torre-Villalvazo, I., Cariño-Cervantes, Y. Y., García-Luna, C., Soberanes-Chávez, P., De Gortari, P., Noriega, L. G., Bautista, C. J., & Cisneros-Zevallos, L. (2023). Cardamom (Elettaria cardamomum (L.) Maton) Seeds Intake Increases Energy Expenditure and Reduces Fat Mass in Mice by Modulating Neural Circuits That Regulate Adipose Tissue Lipolysis and Mitochondrial Oxidative Metabolism in Liver and Skeletal Muscle. International Journal of Molecular Sciences, 24(4), 3909. https://doi.org/10.3390/ijms24043909
33. Drishya, S., Dhanisha, S. S., & Guruvayoorappan, C. (2021a). Anti-Inflammatory Potential Exhibited by Amomum subulatum Fruits Mitigates Experimentally Induced Acute and Chronic Inflammation in Mice: Evaluation of Antioxidant Parameters, Pro-Inflammatory Mediators and HO-1 Pathway. Journal of the American College of Nutrition, 40(6), 551–561. https://doi.org/10.1080/07315724.2020.1806139
34. Drishya, S., Dhanisha, S. S., & Guruvayoorappan, C. (2021b). Anti-Inflammatory Potential Exhibited by Amomum subulatum Fruits Mitigates Experimentally Induced Acute and Chronic Inflammation in Mice: Evaluation of Antioxidant Parameters, Pro-Inflammatory Mediators and HO-1 Pathway. Journal of the American College of Nutrition, 40(6), 551–561. https://doi.org/10.1080/07315724.2020.1806139
35. Drishya, S., Dhanisha, S. S., & Guruvayoorappan, C. (2022a). Antioxidant‐rich fraction of Amomum subulatum fruits mitigates experimental methotrexate‐induced oxidative stress by regulating TNF‐α, IL‐1β, and IL‐6 proinflammatory cytokines. Journal of Food Biochemistry, 46(4). https://doi.org/10.1111/jfbc.13855
36. Drishya, S., Dhanisha, S. S., & Guruvayoorappan, C. (2022b). Antioxidant-rich fraction of Amomum subulatum fruits mitigates experimental methotrexate-induced oxidative stress by regulating TNF-α, IL-1β, and IL-6 proinflammatory cytokines. Journal of Food Biochemistry, 46(4), e13855. https://doi.org/10.1111/jfbc.13855
37. Drishya, S., Dhanisha, S. S., & Guruvayoorappan, C. (2022c). Antioxidant‐rich fraction of Amomum subulatum fruits mitigates experimental methotrexate‐induced oxidative stress by regulating TNF‐α, IL‐1β, and IL‐6 proinflammatory cytokines. Journal of Food Biochemistry, 46(4). https://doi.org/10.1111/jfbc.13855
38. Drishya, S., Dhanisha, S. S., & Guruvayoorappan, C. (2022d). Antioxidant‐rich fraction of Amomum subulatum fruits mitigates experimental methotrexate‐induced oxidative stress by regulating TNF‐α, IL‐1β, and IL‐6 proinflammatory cytokines. Journal of Food Biochemistry, 46(4). https://doi.org/10.1111/jfbc.13855
39. Drishya, S., Dhanisha, S. S., & Guruvayoorappan, C. (2022e). Antioxidant‐rich fraction of Amomum subulatum fruits mitigates experimental methotrexate‐induced oxidative stress by regulating TNF‐α, IL‐1β, and IL‐6 proinflammatory cytokines. Journal of Food Biochemistry, 46(4). https://doi.org/10.1111/jfbc.13855
40. Drishya, S., Dhanisha, S. S., & Guruvayoorappan, C. (2022f). Antioxidant‐rich fraction of Amomum subulatum fruits mitigates experimental methotrexate‐induced oxidative stress by regulating TNF‐α, IL‐1β, and IL‐6 proinflammatory cytokines. Journal of Food Biochemistry, 46(4). https://doi.org/10.1111/jfbc.13855
41. Drishya, S., Dhanisha, S. S., & Guruvayoorappan, C. (2022g). Antioxidant‐rich fraction of Amomum subulatum fruits mitigates experimental methotrexate‐induced oxidative stress by regulating TNF‐α, IL‐1β, and IL‐6 proinflammatory cytokines. Journal of Food Biochemistry, 46(4). https://doi.org/10.1111/jfbc.13855
42. Drishya, S., Dhanisha, S. S., & Guruvayoorappan, C. (2022h). Antioxidant‐rich fraction of Amomum subulatum fruits mitigates experimental methotrexate‐induced oxidative stress by regulating TNF‐α, IL‐1β, and IL‐6 proinflammatory cytokines. Journal of Food Biochemistry, 46(4). https://doi.org/10.1111/jfbc.13855
43. Drishya, S., Dhanisha, S. S., & Guruvayoorappan, C. (2022i). Antioxidant‐rich fraction of Amomum subulatum fruits mitigates experimental methotrexate‐induced oxidative stress by regulating TNF‐α, IL‐1β, and IL‐6 proinflammatory cytokines. Journal of Food Biochemistry, 46(4). https://doi.org/10.1111/jfbc.13855
44. Drishya, S., Dhanisha, S. S., Raghukumar, P., & Guruvayoorappan, C. (2022). Amomum subulatum mitigates total body irradiation-induced oxidative stress and its associated inflammatory response by enhancing the antioxidant status and regulating the pro-inflammatory cytokines. The Journal of Nutritional Biochemistry, 107, 109064. https://doi.org/10.1016/j.jnutbio.2022.109064
45. Epuri, V., Prathap, L., Reddy, V., & Krishnan, M. (2023). Anti oxidative/neuro-inflammation properties of Withania somnifera root extract on rotenone induced stress in rat brain. Bioinformation, 19(6), 729–738. https://doi.org/10.6026/97320630019729
46. Gao, X.-Y., Yang, T., Gu, Y., & Sun, X.-H. (2022). Mitochondrial Dysfunction in Parkinson’s Disease: From Mechanistic Insights to Therapy. Frontiers in Aging Neuroscience, 14, 885500. https://doi.org/10.3389/fnagi.2022.885500
47. Gazmer, A., Chakraborty, M., Chutia, D., Bhattacharjee, A., & Bhuyan, N. R. (2023). Antiparkinsonian effects of Indian spice Amomum subulatum fruit extract by modulating the behavioural, inflammatory markers, antioxidant, and histopathology parameters in rats. Brain Behavior and Immunity Integrative, 3, 100015. https://doi.org/10.1016/j.bbii.2023.100015
48. Indrayanto, G. (2022). The importance of method validation in herbal drug research. Journal of Pharmaceutical and Biomedical Analysis, 214, 114735. https://doi.org/10.1016/j.jpba.2022.114735
49. Khalid, M. U., Sultan, M. T., Baig, I., Abbas, A., Noman, A. M., Zinedine, A., Bartkiene, E., & Rocha, J. M. (2025). A comprehensive review on the bioactivity and pharmacological attributes of Withania somnifera. Natural Product Research, 1–15. https://doi.org/10.1080/14786419.2025.2499070
50. Lerose, V., Ponticelli, M., Benedetto, N., Carlucci, V., Lela, L., Tzvetkov, N. T., & Milella, L. (2024a). Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review. Plants, 13(6), 771. https://doi.org/10.3390/plants13060771
51. Lerose, V., Ponticelli, M., Benedetto, N., Carlucci, V., Lela, L., Tzvetkov, N. T., & Milella, L. (2024b). Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review. Plants, 13(6), 771. https://doi.org/10.3390/plants13060771
52. Lyu, S., Zhang, C. S., Mao, Z., Guo, X., Li, Z., Luo, X., Sun, J., & Su, Q. (2024). Real-world Chinese herbal medicine for Parkinson’s disease: A hospital-based retrospective analysis of electronic medical records. Frontiers in Aging Neuroscience, 16, 1362948. https://doi.org/10.3389/fnagi.2024.1362948
53. McCaig, L. F. (1994). National Hospital Ambulatory Medical Care Survey: 1992 outpatient department summary. Advance Data, 248, 1–12.
54. Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., Szeląg, M., Szklanny, D., Judasz, E., Kaczmarek, G., Ejiohuo, O. P., Paczkowska-Walendowska, M., Gościniak, A., & Cielecka-Piontek, J. (2023a). Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics, 15(4), 1057. https://doi.org/10.3390/pharmaceutics15041057
55. Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., Szeląg, M., Szklanny, D., Judasz, E., Kaczmarek, G., Ejiohuo, O. P., Paczkowska-Walendowska, M., Gościniak, A., & Cielecka-Piontek, J. (2023b). Ashwagandha (Withania somnifera)-Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics, 15(4), 1057. https://doi.org/10.3390/pharmaceutics15041057
56. Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., Szeląg, M., Szklanny, D., Judasz, E., Kaczmarek, G., Ejiohuo, O. P., Paczkowska-Walendowska, M., Gościniak, A., & Cielecka-Piontek, J. (2023c). Ashwagandha (Withania somnifera)-Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics, 15(4), 1057. https://doi.org/10.3390/pharmaceutics15041057
57. Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., Szeląg, M., Szklanny, D., Judasz, E., Kaczmarek, G., Ejiohuo, O. P., Paczkowska-Walendowska, M., Gościniak, A., & Cielecka-Piontek, J. (2023d). Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics, 15(4), 1057. https://doi.org/10.3390/pharmaceutics15041057
58. Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., Szeląg, M., Szklanny, D., Judasz, E., Kaczmarek, G., Ejiohuo, O. P., Paczkowska-Walendowska, M., Gościniak, A., & Cielecka-Piontek, J. (2023e). Ashwagandha (Withania somnifera)-Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics, 15(4), 1057. https://doi.org/10.3390/pharmaceutics15041057
59. Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., Szeląg, M., Szklanny, D., Judasz, E., Kaczmarek, G., Ejiohuo, O. P., Paczkowska-Walendowska, M., Gościniak, A., & Cielecka-Piontek, J. (2023f). Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics, 15(4), 1057. https://doi.org/10.3390/pharmaceutics15041057Modi, S. J., Tiwari, A., Ghule, C., Pawar, S., Saste, G., Jagtap, S., Singh, R., Deshmukh, A., Girme, A., & Hingorani, L. (2022). Pharmacokinetic Study of Withanosides and Withanolides from Withania somnifera Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS). Molecules (Basel, Switzerland), 27(5), 1476. https://doi.org/10.3390/molecules27051476
60. Peggion, C., Calì, T., & Brini, M. (2024). Mitochondria Dysfunction and Neuroinflammation in Neurodegeneration: Who Comes First? Antioxidants, 13(2), 240. https://doi.org/10.3390/antiox13020240
61. Pereira, G. M., Teixeira-Dos-Santos, D., Soares, N. M., Marconi, G. A., Friedrich, D. C., Saffie Awad, P., Santos-Lobato, B. L., Brandão, P. R. P., Noyce, A. J., Marras, C., Mata, I. F., Rieder, C. R. de M., & Schuh, A. F. S. (2024). A systematic review and meta-analysis of the prevalence of Parkinson’s disease in lower to upper-middle-income countries. NPJ Parkinson’s Disease, 10(1), 181. https://doi.org/10.1038/s41531-024-00779-y
62. Pizarro-Galleguillos, B. M., Kunert, L., Brüggemann, N., & Prasuhn, J. (2023a). Neuroinflammation and Mitochondrial Dysfunction in Parkinson’s Disease: Connecting Neuroimaging with Pathophysiology. Antioxidants (Basel, Switzerland), 12(7), 1411. https://doi.org/10.3390/antiox12071411
63. Pizarro-Galleguillos, B. M., Kunert, L., Brüggemann, N., & Prasuhn, J. (2023b). Neuroinflammation and Mitochondrial Dysfunction in Parkinson’s Disease: Connecting Neuroimaging with Pathophysiology. Antioxidants (Basel, Switzerland), 12(7), 1411. https://doi.org/10.3390/antiox12071411
64. Prakash, J., Chouhan, S., Yadav, S. K., Westfall, S., Rai, S. N., & Singh, S. P. (2014). Withania somnifera alleviates parkinsonian phenotypes by inhibiting apoptotic pathways in dopaminergic neurons. Neurochemical Research, 39(12), 2527–2536. https://doi.org/10.1007/s11064-014-1443-7
65. Pringsheim, T., Jette, N., Frolkis, A., & Steeves, T. D. L. (2014). The prevalence of Parkinson’s disease: A systematic review and meta‐analysis. Movement Disorders, 29(13), 1583–1590. https://doi.org/10.1002/mds.25945
66. Radad, K., Moldzio, R., Krewenka, C., Kranner, B., & Rausch, W.-D. (2023). Pathophysiology of non-motor signs in Parkinson’s disease: Some recent updating with brief presentation. Exploration of Neuroprotective Therapy, 24–46. https://doi.org/10.37349/ent.2023.00036
67. Rahman, Md. M., Wang, X., Islam, Md. R., Akash, S., Supti, F. A., Mitu, M. I., Harun-Or-Rashid, Md., Aktar, Most. N., Khatun Kali, Most. S., Jahan, F. I., Singla, R. K., Shen, B., Rauf, A., & Sharma, R. (2022). Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance. Frontiers in Pharmacology, 13, 976385. https://doi.org/10.3389/fphar.2022.976385
68. Regulation and standardization of herbal drugs: Current status, limitation, challenge’s and future prospective. (2024). In Profiles of Drug Substances, Excipients and Related Methodology (Vol. 49, pp. 153–199). Elsevier. https://doi.org/10.1016/bs.podrm.2023.11.003
69. Shen, L., & Dettmer, U. (2024). Alpha-Synuclein Effects on Mitochondrial Quality Control in Parkinson’s Disease. Biomolecules, 14(12), 1649. https://doi.org/10.3390/biom14121649
70. Tanner, C. M., & Ostrem, J. L. (2024). Parkinson’s Disease. New England Journal of Medicine, 391(5), 442–452. https://doi.org/10.1056/NEJMra2401857
71. Tyler, S. E. B., & Tyler, L. D. K. (2023). Pathways to healing: Plants with therapeutic potential for neurodegenerative diseases. IBRO Neuroscience Reports, 14, 210–234. https://doi.org/10.1016/j.ibneur.2023.01.006
72. Vaidya, V. G., Gothwad, A., Ganu, G., Girme, A., Modi, S. J., & Hingorani, L. (2024). Clinical safety and tolerability evaluation of Withania somnifera (L.) Dunal (Ashwagandha) root extract in healthy human volunteers. Journal of Ayurveda and Integrative Medicine, 15(1), 100859. https://doi.org/10.1016/j.jaim.2023.100859
73. Vaidya, V. G., Naik, N. N., Ganu, G., Parmar, V., Jagtap, S., Saste, G., Bhatt, A., Mulay, V., Girme, A., Modi, S. J., & Hingorani, L. (2024). Clinical pharmacokinetic evaluation of Withania somnifera (L.) Dunal root extract in healthy human volunteers: A non-randomized, single dose study utilizing UHPLC-MS/MS analysis. Journal of Ethnopharmacology, 322, 117603. https://doi.org/10.1016/j.jep.2023.117603
74. Yang, Y., Zhang, Z., Li, S., Ye, X., Li, X., & He, K. (2014). Synergy effects of herb extracts: Pharmacokinetics and pharmacodynamic basis. Fitoterapia, 92, 133–147. https://doi.org/10.1016/j.fitote.2013.10.010