Authors : Thièry Ndong Mba; Kouassi Karl Nzaou-Tchokoto; Ulrich Lowens Onkassa-Sah; Hilaire Moundounga Kenguele

Volume/Issue : Volume 11 - 2026, Issue 9 - September

---

Google Scholar : https://tinyurl.com/7k7zd7be

DOI : https://doi.org/10.38124/ijisrt/26sep340

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

---

Abstract : Background: Transfusion-transmissible infections (TTIs) remain a major public health concern in resource-limited settings. This study aimed to determine the seroprevalence of HBV, HCV, HIV, and syphilis among blood donors in Ngounié province, Gabon, an area previously lacking epidemiological data.  Methods: A cross-sectional study was conducted from July 2025 to March 2026 at the Mouila Regional Hospital Center. A total of 482 donors were screened using rapid immunochromatographic assays. Sociodemographic data and behavioral risk factors were collected and analyzed using Python.

Keywords : Transfusion-Transmissible Infections; Blood Donors; Seroprevalence; Family Replacement Donation; Hepatitis B Virus; Gabon.

References :

1. Health Product Policy and Standards. Global status report on blood safety and availability 2021 [Internet]. 2022. Available from: https://www.who.int/publications/i/item/9789240051683
2. World Health Organization. Global status report on blood safety and availability 2016. Geneva. 2017.
3. Bloch EM, Vermeulen M, Murphy E. Blood Transfusion Safety in Africa. A Literature Review. Transfus Med Rev. 2013;26(2):164–80.
4. Eko Mba JM, Bisseye C, Ntsame Ndong JM, Mombo LE, Bengone C, Migolet GM, et al. Prevalent hepatitis B surface antigen among first-time blood donors in Gabon. PLoS One. 2018;13(4):1–10.
5. Tonda J, Mickala P, Mombo L-E, Mengue J-CE, Mongo-Délis A, Mbacky K, et al. Séroprévalence du virus de l’immunodéficience humaine, des virus des hépatites B et C et de Treponema pallidum chez les donneurs de sang dans une zone rurale au sud-est Gabon (Koula-Moutou). J Appl Biosci. 2017;110(1):10783.
6. Bisseye C, Mombo LE, Bie SMM, Edou A, Mba JME, Etho-Mengue JC, et al. Trends of blood-borne infectious diseases in a rural blood donation center of southeast gabon (Koula-moutou). Pan Afr Med J. 2018;31:1–10.
7. Hilaire MOUNDOUNGA KENGUELE, Bourdettes MEYE, Thièry NDONG MBA, Ulrich Lowens ONKASSA-SAH, Alain SOUZA. Prevalence of transfusion-transmissible infections among Blood Donors Attending the Regional Hospital Center of Franceville (Southern Gabon). Open Access Res J Biol Pharm. 2023;9(2):014–20.
8. Mremi A, Yahaya JJ, Nyindo M, Mollel E. Transfusion-Transmitted Infections and associated risk factors at the Northern Zone Blood Transfusion Center in Tanzania: A study of blood donors between 2017 and 2019. PLoS One [Internet]. 2021;16(3 March):1–12. Available from: http://dx.doi.org/10.1371/journal.pone.0249061
9. Adusei KA, Owusu-Ofori A. Prevalence of plasmodium parasitaemia in blood donors and a survey of the knowledge, attitude and practices of transfusion malaria among health workers in a hospital in kumasi, Ghana. PLoS One. 2018;13(11):1–12.
10. Buseri FI, Muhibi MA, Jeremiah ZA. Sero-epidemiology of transfusion-transmissible infectious diseases among blood donors in Osogbo, south-west Nigeria. Blood Transfus. 2009;7(4):293–9.
11. Biadgo B, Shiferaw E, Woldu B, Alene KA, Melku M. Transfusion-transmissible viral infections among blood donors at the North Gondar district blood bank, northwest Ethiopia: A three year retrospective study. PLoS One. 2017;12(7):1–12.
12. Gebreyes DS, Kifetew K, Gizaw A, Abebe TA, Shenkutie TT, Genetu D, et al. Prevalence and Risk Factors of Transfusion-Transmissible Infections Among Voluntary Blood Donors in North Shoa, Amhara Region, Ethiopia: A Cross-Sectional Study. Heal Sci Reports. 2025;8(5).
13. Charbonneau J, Cloutier MS, Carrier É. Why Do Blood Donors Lapse or Reduce Their Donation’s Frequency? Transfus Med Rev. 2016;30(1):1–5.
14. Mangala C, Maulot-Bangola D, Moutsinga A, Okolongo-Mayani SC, Matsomo-Kombet GE, Moundanga M, et al. Prevalence and factors associated with transfusion-transmissible infections (HIV, HBV, HCV and Syphilis) among blood donors in Gabon: Systematic review and meta-analysis. PLoS One [Internet]. 2024;19(8):1–17. Available from: http://dx.doi.org/10.1371/journal.pone.0307101
15. Weimer A, Tagny CT, Tapko JB, Gouws C, Tobian AAR, Ness PM, et al. Blood transfusion safety in sub-Saharan Africa: A literature review of changes and challenges in the 21st century. Transfusion. 2019;59(1):412–27.
16. UNAIDS. Global HIV and AIDS Statistics Fact sheet: HIV estimates with uncertainty bounds 1990-present. [Internet]. 2026. Available from: https://www.unaids.org/en/resources/fact-sheet
17. Tagny CT, Diarra A, Yahaya R, Hakizimana M, Nguessan A, Mbensa G, et al. Characteristics of blood donors and donated blood in sub-Saharan Francophone Africa. Transfusion. 2009;49(8):1592–9.
18. Nasrallah GK, Al-Buainain R, Younes N, Dargham SR, Al-Sadeq DW, Elhassan M, et al. Screening and diagnostic testing protocols for HIV and Syphilis infections in health care setting in Qatar: Evaluation and recommendations. PLoS One [Internet]. 2023;18(2 February):1–14. Available from: http://dx.doi.org/10.1371/journal.pone.0278079
19. Prinsze FJ, van de Laar T, Slot E, de Jong M, Bokhorst A, de Kort W, et al. No increased risk of transfusion-transmissible infections after tattooing, body piercing, or acupuncture among blood donors in the Netherlands. Transfusion. 2019;59(8):2575–83.
20. Samo AA, Laghari ZA, Baig NM, Khoso GM. Prevalence and Risk Factors Associated with Hepatitis B and C in Nawabshah, Sindh, Pakistan. Am J Trop Med Hyg. 2021;104(3):1101–5.
21. Lowe H, Woodd S, Lange IL, Janjanin S, Barnett J, Graham W. Challenges and opportunities for infection prevention and control in hospitals in conflict-affected settings: a qualitative study. Confl Health. 2021;15(1):1–10.