Authors : Dr. Gayathri Rajaram; Charan Prakash Krishnan; Monika Sekar; Tamil Selvi Sriraman

Volume/Issue : Volume 10 - 2025, Issue 7 - July

Google Scholar : https://tinyurl.com/yt4chd8m

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DOI : https://doi.org/10.38124/ijisrt/25jul1184

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Abstract : Poor water solubility remains a key challenge in the oral delivery of many active pharmaceutical ingredients (APIs), particularly those in BCS Class II and IV, often resulting in low bioavailability and limited therapeutic effect. Solid dispersion (SD) technology has gained widespread attention as a practical and effective solution to this issue by improving solubility and dissolution rates. This review outlines recent developments in SD systems, including novel carriers, advanced techniques like hot-melt extrusion and spray drying, and polymer innovations that support stable amorphous drug formulations. It also covers SD classification, analytical methods such as DSC and TMDSC, and the mechanisms behind enhanced drug absorption. Overall, solid dispersions are emphasized as a flexible, efficient, and commercially promising approach to boost the oral bioavailability of poorly soluble APIs.

Keywords : Solid Dispersion, Bioavailability Enhancement, Amorphous Drug, Surfactant, Solubility Improvement.

References :

1. Singh S, Baghel RS, Yadav L. A review on solid dispersion. International journal of pharmacy & life sciences. 2011;2(9).
2. Nokhodchi A, Javadzadeh Y, Siahi-Shadbad MR, Barzegar-Jalali M. The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug (indomethacin) from liquisolid compacts. Journal of Pharmacy and pharmaceutical Sciences. 2005;8(1):18-25.
3. Bakatselou V, Oppenheim RC, Dressman JB. Solubilization and wetting effects of bile salts on the dissolution of steroids. Pharmaceutical research. 1991;8:1461-9.
4. Gurunath S, Kumar SP, Basavaraj NK, Patil PA. Amorphous solid dispersion method for improving oral bioavailability of poorly water-soluble drugs. journal of pharmacy research. 2013;6(4):476-80.
5. Noyes AA, Whitney WR. The rate of solution of solid substances in their own solutions. Journal of the American Chemical Society. 1897;19(12):930-4.
6. Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. European journal of Pharmaceutics and Biopharmaceutics. 2000;50(1):47-60.
7. Dixit AK, Singh RP, Singh S. Solid dispersion-a strategy for improving the solubility of poorly soluble drugs. International Journal of Research in Pharmaceutical and Biomedical Sciences. 2012;3(2):960-6.
8. Vasconcelos T, Sarmento B, Costa P. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug discovery today. 2007;12(23-24):1068-75.
9. Singh S, Baghel RS, Yadav L. A review on solid dispersion. International journal of pharmacy & life sciences. 2011;2(9).
10. Saffoon N, Uddin R, Huda NH, Sutradhar KB. Enhancement of oral bioavailability and solid dispersion: a review. Journal of Applied Pharmaceutical Science. 2011:13-20.
11. Sharma A, Jain CP. Solid dispersion: A promising technique to enhance solubility of poorly water soluble drug. International Journal of Drug Delivery. 2011;3(2):149.
12. Das SK, Roy S, Kalimuthu Y, Khanam J, Nanda A. Solid dispersions: an approach to enhance the bioavailability of poorly water-soluble drugs. International journal of pharmacology and pharmaceutical technology. 2012;1(1):37-46.
13. Serajuddin AT. Solid dispersion of poorly water‐soluble drugs: Early promises, subsequent problems, and recent breakthroughs. Journal of pharmaceutical sciences. 1999;88(10):1058-66.
14. Rasenack N, Müller BW. Micron‐size drug particles: common and novel micronization techniques. Pharmaceutical development and technology. 2004;9(1):1-3.
15. Kumar B. Solid dispersion-a review. PharmaTutor. 2017;5(2):24-9.
16. Vasanthavada M, Tong WQ, Joshi Y, Kislalioglu MS. Phase behavior of amorphous molecular dispersions I: Determination of the degree and mechanism of solid solubility. Pharmaceutical research. 2004;21:1598-606.
17. Wang X, Michoel A, Van den Mooter G. Solid state characteristics of ternary solid dispersions composed of PVP VA64, Myrj 52 and itraconazole. International journal of pharmaceutics. 2005;303(1-2):54-61.
18. Won DH, Kim MS, Lee S, Park JS, Hwang SJ. Improved physicochemical characteristics of felodipine solid dispersion particles by supercritical anti-solvent precipitation process. International journal of pharmaceutics. 2005;301(1-2):199-208.
19. Ohara T, Kitamura S, Kitagawa T, Terada K. Dissolution mechanism of poorly water-soluble drug from extended release solid dispersion system with ethylcellulose and hydroxypropylmethylcellulose. International journal of pharmaceutics. 2005;302(1-2):95-102.
20. Bates TR. Dissolution characteristics of reserpine‐polyvinylpyrrolidone co‐precipitates. Journal of Pharmacy and Pharmacology. 1969;21(10):710-2.
21. Moyano JR, Arias-Blanco MJ, Gines JM, Giordano F. Solid-state characterization and dissolution characteristics of gliclazide-β-cyclodextrin inclusion complexes. International journal of pharmaceutics. 1997;148(2):211-7.
22. Nasikkar Z, Tiwari S, Vishwakarma R, Tarmale P, Verma N, Turerao M. Solid dispersion: A review. World Journal of Pharmaceutical Research. 2024;13(9):271-87.
23. Nokhodchi A, Talari R, Valizadeh H, Jalali MB. An investigation on the solid dispersions of chlordiazepoxide. International journal of biomedical science: IJBS. 2007;3(3):211.
24. Bhise SB, Rajkumar M. Effect of HPMC on solubility and dissolution of carbamazepine form III in simulated gastrointestinal fluids. Asian Journal of Pharmaceutics (AJP). 2008;2(1).
25. Perissutti B, Newton JM, Podczeck F, Rubessa F. Preparation of extruded carbamazepine and PEG 4000 as a potential rapid release dosage form. European journal of pharmaceutics and biopharmaceutics. 2002;53(1):125-32.
26. Zhang W, Yan E, Huang Z, Wang C, Xin Y, Zhao Q, Tong Y. Preparation and study of PPV/PVA nanofibers via electrospinning PPV precursor alcohol solution. European polymer journal. 2007;43(3):802-7.
27. Narang A, Shrivastava A. Melt extrusion solid dispersion technique. Drug Dev. Ind. Pharm. 2002;26(8):111-5.
28. Jigar V, Jayvadan P, Jain DA. Enhancement of dissolution rate of modafinil using solid dispersions with polyethyleneglycols. Indonesian Journal of Pharmacy. 2012;23:209-15.
29. Asker AF, Whitworth CW. Dissolution of acetylsalicylic acid from acetylsalicylic acid-polyethylene glycol 6000 coprecipitates. Die Pharmazie. 1975;30(8):530-1.
30. Walking WD, Wade A, Weller PJ. Handbook of Pharmaceutical Excipitients, American Pharmaceutical Association.
31. Buehler V. Soluble Kollidon Grades (Povidone, Polyvidone): Tablet Coatings. Kollidon: Polyvinylpyrrolidone for the Pharmaceutical Industry, BASF, Ludwigshafen. 1993:106-15.
32. Nikghalb LA, Singh G, Singh G, Kahkeshan KF. Solid Dispersion: Methods and Polymers to increase the solubility of poorly soluble drugs. Journal of Applied Pharmaceutical Science. 2012;2(10):170-5.
33. Okimoto K, Miyake M, Ibuki R, Yasumura M, Ohnishi N, Nakai T. Dissolution mechanism and rate of solid dispersion particles of nilvadipine with hydroxypropylmethylcellulose. International journal of pharmaceutics. 1997;159(1):85-93.
34. Kai T, AKIYAMA Y, NOMURA S, SATo M. Oral absorption improvement of poorly soluble drug using solid dispersion technique. Chemical and pharmaceutical bulletin. 1996;44(3):568-71.
35. Taylor LS, Zografi G. Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions. Pharmaceutical research. 1997;14:1691-8.
36. Buckton G, Darcy P. The use of gravimetric studies to assess the degree of crystallinity of predominantly crystalline powders. International Journal of Pharmaceutics. 1995;123(2):265-71.
37. Sebhatu T, Angberg M, Ahlneck C. Assessment of the degree of disorder in crystalline solids by isothermal microcalorimetry. International Journal of Pharmaceutics. 1994;104(2):135-44.
38. Pikal MJ, Lukes AL, Lang JE, Gaines K. Quantitative crystallinity determinations for β-lactam antibiotics by solution calorimetry: Correlations with stability. Journal of pharmaceutical sciences. 1978;67(6):767-73.
39. Kerc J, Srcic S. Thermal analysis of glassy pharmaceuticals. Thermochimica acta. 1995;248:81-95.
40. De Meuter P, Rahier H, Van Mele B. The use of modulated temperature differential scanning calorimetry for the characterisation of food systems. International Journal of Pharmaceutics. 1999;192(1):77-84.
41. Cilurzo F, Minghetti P, Casiraghi A, Montanari L. Characterization of nifedipine solid dispersions. International journal of pharmaceutics. 2002;242(1-2):313-7.
42. Vasanthavada M, Tong WQ, Joshi Y, Kislalioglu MS. Phase behavior of amorphous molecular dispersions I: Determination of the degree and mechanism of solid solubility. Pharmaceutical research. 2004;21:1598-606.