Sickle cell disease (SCD) is the most common inherited disorders of hemoglobinopathies in the worldwide and represents a major public health problem in Arab countries especially Yemen. One of the most SCD is the asymptomatic heterozygotes (HbSA) sickle cell trait (SCT) carriers. The aim of the current study was to determine the prevalence of SCT, gender differences, and Full blood cells (FBC) parameters among school students in Taiz city, Yemen. A cross-sectional study was conducted on two hundred and seventy blood samples were subjected to sickling and FBC tests. One hundred thirty seven boys (50.7%) and one hundred thirty three girls (34.8%), nineteen blood samples were found sickling test positive, thirteen boys (68%) and six girls (32%) with overall prevalence of SCT among all students was 7.0% (4.8% boys and 2.2 % girls). 77% of boys and 33% of girls SCT carriers were found their parents having consanguineous marriage with statistically significant difference (p=0.007). FBC results of SCT students showed significantly lower compared to normal students(p=0.01). In conclusion: SCT carrier is highly prevalence among population in Taiz city as well as other parts of Yemen, these could be contributed to the highest degree of firstcousin consanguineous marriage and endemic malaria in this city

Keywords : Sickle Cell Diseases (SCD), Sickle Cell Trait (SCT), Students, School, Taiz, Yemen