Authors :
Hasan A. M. M. Almansoub; Rowdh Almansoob
Volume/Issue :
2nd ICTSA-2022
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://bit.ly/3ZenW4q
DOI :
https://doi.org/10.5281/zenodo.7765559
Abstract :
Neurodegenerative diseases are characterized
by progressive damage in neural cells and neuronal loss;
bearing in mind the relevance of oxidative stress in
neurodegenerative diseases, including Alzheimer's and
Parkinson's diseases, and the antioxidant properties of
oxytocin, which we previously demonstrated, we studied
the effects of oxytocin administration 5µM oxytocin for
24h, on enzymatic activities of superoxide dismutase
(SOD) and malonic dialdehyde (MDA) level in the
Neuro2a cells (N2a cell lines ) which treated by 250 µM
hydrogen peroxide( H2O2 ) for 24h. In these cells,
oxytocin treatment provided a significantly lower SOD
enzymatic activity and significantly higher MDA
concentration. It is concluded that, due to its antioxidant
effect, oxytocin can be considered a candidate for
developing a new therapeutic modality in
neurodegenerative diseases.
Keywords :
Neurodegenerative Diseases, Oxidative Stress, Oxytocin, Superoxide Dismutase, Malonic Dialdehyde, Neuro2a cells.
Neurodegenerative diseases are characterized
by progressive damage in neural cells and neuronal loss;
bearing in mind the relevance of oxidative stress in
neurodegenerative diseases, including Alzheimer's and
Parkinson's diseases, and the antioxidant properties of
oxytocin, which we previously demonstrated, we studied
the effects of oxytocin administration 5µM oxytocin for
24h, on enzymatic activities of superoxide dismutase
(SOD) and malonic dialdehyde (MDA) level in the
Neuro2a cells (N2a cell lines ) which treated by 250 µM
hydrogen peroxide( H2O2 ) for 24h. In these cells,
oxytocin treatment provided a significantly lower SOD
enzymatic activity and significantly higher MDA
concentration. It is concluded that, due to its antioxidant
effect, oxytocin can be considered a candidate for
developing a new therapeutic modality in
neurodegenerative diseases.
Keywords :
Neurodegenerative Diseases, Oxidative Stress, Oxytocin, Superoxide Dismutase, Malonic Dialdehyde, Neuro2a cells.
