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Stem Cells: Potential and Challenges in Regenerative Medicine-A Quantitative and Translational Perspective


Authors : Mukesh Kumari; Dr. Kusum Lata

Volume/Issue : Volume 11 - 2026, Issue 3 - March


Google Scholar : https://tinyurl.com/wkm8uvb3

Scribd : https://tinyurl.com/28n2439c

DOI : https://doi.org/10.38124/ijisrt/26mar1500

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : Stem cells have revolutionized regenerative medicine due to their self-renewal and differentiation capabilities. Over the past three decades, advances in stem cell biology have enabled therapeutic applications for degenerative diseases, injuries, and genetic disorders. This paper explores the biological potential, clinical applications, quantitative growth trends, and major challenges in stem cell-based regenerative medicine. Additionally, it proposes a novel integrative framework combining artificial intelligence (AI) and personalized stem cell therapy to overcome translational bottlenecks.

References :

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  2. A. Atala, R. Lanza Handbook of Stem Cells Academic press (2012)
  3. N.H. Goradel, F.G. Hour, B. Negahdari, Z.V. Malekshahi, M. Hashemzehi, A. Masoudifar, H. Mirzaei Stem cell therapy: a new therapeutic option for cardiovascular diseases J. Cell Biochem., 119 (2018), pp. 95-104.
  4. N.J. Hogrebe, M. Ishahak, J.R. Millman Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes Cell Stem Cell, 30 (2023), pp. 530-548.
  5. Lee CS, Lee M, Na K, Hwang HS. Stem cell-derived extracellular vesicles for cancer therapy and tissue engineering applications. Molecular Pharmaceutics. 2023 Oct 23;20(11):5278-311.
  6. Kim HK,  Kim TJ.  Current Status  and Future Prospects of Stem  Cell Therapy  for Infertile  Patients with Premature Ovarian Insufficiency. Biomolecules. 2024 Feb 19;14(2):242.
  7. Li YR, Fang Y, Niu S, Chen Y, Lyu Z, Yang L. Managing Allorejection in Off-the-Shelf CAR-Engineered Cell Therapies. Molecular Therapy. 2024 Nov 26.

Stem cells have revolutionized regenerative medicine due to their self-renewal and differentiation capabilities. Over the past three decades, advances in stem cell biology have enabled therapeutic applications for degenerative diseases, injuries, and genetic disorders. This paper explores the biological potential, clinical applications, quantitative growth trends, and major challenges in stem cell-based regenerative medicine. Additionally, it proposes a novel integrative framework combining artificial intelligence (AI) and personalized stem cell therapy to overcome translational bottlenecks.

Paper Submission Last Date
30 - April - 2026

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