Authors :
Mukesh Kumari; Dr. Kusum Lata
Volume/Issue :
Volume 11 - 2026, Issue 3 - March
Google Scholar :
https://tinyurl.com/wkm8uvb3
Scribd :
https://tinyurl.com/28n2439c
DOI :
https://doi.org/10.38124/ijisrt/26mar1500
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Stem cells have revolutionized regenerative medicine due to their self-renewal and differentiation capabilities.
Over the past three decades, advances in stem cell biology have enabled therapeutic applications for degenerative diseases,
injuries, and genetic disorders. This paper explores the biological potential, clinical applications, quantitative growth trends,
and major challenges in stem cell-based regenerative medicine. Additionally, it proposes a novel integrative framework
combining artificial intelligence (AI) and personalized stem cell therapy to overcome translational bottlenecks.
References :
- A.Leyendecker Junior TGF- inhibitor SB431542 promotes the differentiation of induced pluripotent stem cells and embryonic stem cells into mesenchymal-like cells Stem Cells Int., 2018 (2018).
- A. Atala, R. Lanza Handbook of Stem Cells Academic press (2012)
- N.H. Goradel, F.G. Hour, B. Negahdari, Z.V. Malekshahi, M. Hashemzehi, A. Masoudifar, H. Mirzaei Stem cell therapy: a new therapeutic option for cardiovascular diseases J. Cell Biochem., 119 (2018), pp. 95-104.
- N.J. Hogrebe, M. Ishahak, J.R. Millman Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes Cell Stem Cell, 30 (2023), pp. 530-548.
- Lee CS, Lee M, Na K, Hwang HS. Stem cell-derived extracellular vesicles for cancer therapy and tissue engineering applications. Molecular Pharmaceutics. 2023 Oct 23;20(11):5278-311.
- Kim HK, Kim TJ. Current Status and Future Prospects of Stem Cell Therapy for Infertile Patients with Premature Ovarian Insufficiency. Biomolecules. 2024 Feb 19;14(2):242.
- Li YR, Fang Y, Niu S, Chen Y, Lyu Z, Yang L. Managing Allorejection in Off-the-Shelf CAR-Engineered Cell Therapies. Molecular Therapy. 2024 Nov 26.
Stem cells have revolutionized regenerative medicine due to their self-renewal and differentiation capabilities.
Over the past three decades, advances in stem cell biology have enabled therapeutic applications for degenerative diseases,
injuries, and genetic disorders. This paper explores the biological potential, clinical applications, quantitative growth trends,
and major challenges in stem cell-based regenerative medicine. Additionally, it proposes a novel integrative framework
combining artificial intelligence (AI) and personalized stem cell therapy to overcome translational bottlenecks.