Authors :
Vandana R. Daga; Dr. G.D. Basarkar; Dr. C.D. Upasani
Volume/Issue :
Volume 8 - 2023, Issue 5 - May
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/3cxy3ttt
DOI :
https://doi.org/10.5281/zenodo.8077091
Abstract :
The aim of this study was to develop a colontargeted drug delivery system using a co-excipient
prepared by the spray drying technique. The coexcipients used in the formulation containing blend of
polymers for colonic release, the drug used in the study
was Mesalamine, which is a non-steroidal antiinflammatory drug commonly used in the treatment of
various inflammatory conditions. Mesalamine was
directly compressed with spray dried Coexcipient. The in vitro drug release studies were
carried out in simulated gastric and intestinal fluids and
a pH 7.4 phosphate buffer. The release profile of the
formulation showed a sustained drug release in the
intestinal fluid, indicating the colon-targeted drug
delivery of the formulation. Overall, the co-excipientbased formulation prepared by the spray drying
technique showed promising results in terms of its
physicochemical properties and colon-targeted drug
delivery. This study provides a foundation for the
development of novel drug delivery systems for the
treatment of various inflammatory conditions affecting
the colon.
Keywords :
Colon targeting, pH dependent polymers, Spray drying, Coexcipient, Mesalamine.
The aim of this study was to develop a colontargeted drug delivery system using a co-excipient
prepared by the spray drying technique. The coexcipients used in the formulation containing blend of
polymers for colonic release, the drug used in the study
was Mesalamine, which is a non-steroidal antiinflammatory drug commonly used in the treatment of
various inflammatory conditions. Mesalamine was
directly compressed with spray dried Coexcipient. The in vitro drug release studies were
carried out in simulated gastric and intestinal fluids and
a pH 7.4 phosphate buffer. The release profile of the
formulation showed a sustained drug release in the
intestinal fluid, indicating the colon-targeted drug
delivery of the formulation. Overall, the co-excipientbased formulation prepared by the spray drying
technique showed promising results in terms of its
physicochemical properties and colon-targeted drug
delivery. This study provides a foundation for the
development of novel drug delivery systems for the
treatment of various inflammatory conditions affecting
the colon.
Keywords :
Colon targeting, pH dependent polymers, Spray drying, Coexcipient, Mesalamine.
