In that study includes prepared and evaluate the buccal patches of Losartan potassium used various polymers such as an ethyl cellulose, Hydroxypropyl methylcellulose Eudragit 100 in different concentration and combination, like polyvnylalchohol used as plasticizer and Dimethyl sulfoxide used as penetration enhancers. All batches were formulated by solvent casting technique. Losartan potassium an antihypertensive drug has high first pass metabolism so buccal route is superlative for its systemic delivery there by produce excellent bioavailability. Preformulation study performed and patches prepared were assessed for evaluation of different physicochemical parameters like uniformity of weight, thickness, content uniformity and folding endurance. In vitro studies shows that release rate of Losartan potassium was higher from films containing ratio of Eudragit L 100 and Ethyl cellulose in proportion of 2:1 ratio and drug release after 5hrs.Was found to be 95.13%.

Keywords : buccal patch, Losartan Potassium, penetration enhancers, solvent casting technique.