Authors :
Mahesh Mane , Nilesh Patole, Tejaswini Jadhav
Volume/Issue :
Volume 7 - 2022, Issue 11 - November
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3OJ4IQB
DOI :
https://doi.org/10.5281/zenodo.7374802
Abstract :
In that study includes prepared and evaluate
the buccal patches of Losartan potassium used various
polymers such as an ethyl cellulose, Hydroxypropyl
methylcellulose Eudragit 100 in different concentration
and combination, like polyvnylalchohol used as
plasticizer and Dimethyl sulfoxide used as penetration
enhancers. All batches were formulated by solvent
casting technique. Losartan potassium an
antihypertensive drug has high first pass metabolism so
buccal route is superlative for its systemic delivery there
by produce excellent bioavailability. Preformulation
study performed and patches prepared were assessed for
evaluation of different physicochemical parameters like
uniformity of weight, thickness, content uniformity and
folding endurance. In vitro studies shows that release
rate of Losartan potassium was higher from films
containing ratio of Eudragit L 100 and Ethyl cellulose in
proportion of 2:1 ratio and drug release after 5hrs.Was
found to be 95.13%.
Keywords :
buccal patch, Losartan Potassium, penetration enhancers, solvent casting technique.
In that study includes prepared and evaluate
the buccal patches of Losartan potassium used various
polymers such as an ethyl cellulose, Hydroxypropyl
methylcellulose Eudragit 100 in different concentration
and combination, like polyvnylalchohol used as
plasticizer and Dimethyl sulfoxide used as penetration
enhancers. All batches were formulated by solvent
casting technique. Losartan potassium an
antihypertensive drug has high first pass metabolism so
buccal route is superlative for its systemic delivery there
by produce excellent bioavailability. Preformulation
study performed and patches prepared were assessed for
evaluation of different physicochemical parameters like
uniformity of weight, thickness, content uniformity and
folding endurance. In vitro studies shows that release
rate of Losartan potassium was higher from films
containing ratio of Eudragit L 100 and Ethyl cellulose in
proportion of 2:1 ratio and drug release after 5hrs.Was
found to be 95.13%.
Keywords :
buccal patch, Losartan Potassium, penetration enhancers, solvent casting technique.
