Authors :
Dr. T. AYYAPPAN; G. SARANYA; R.VIGNESWARAN; Dr. T. VETRICHELVAN
Volume/Issue :
Volume 8 - 2023, Issue 3 - March
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://bit.ly/407U5M6
DOI :
https://doi.org/10.5281/zenodo.7758381
Abstract :
The Mucoadhesive drug delivery system was
a new approach in pharmaceutical field and drug
retention for a prolonged time has been achieved.
Rosuvastatin calcium is a HMG-CoA Reductase
inhibitors (statins) used in the treatment of
percholesterolemia or hyperlipidemia. Mucoadhesive
micro beads of Rosuvastatin calcium were successfully
prepared by Ionotropic gelation technique. Central
composite design was applied for the preparation and
optimization of mucoadhesive microbeads using
Statease-Design of Experiment Version–12 software. The
results of preformulation studies showed that there was
no interaction between the drug and polymer. The
polymers used in the microbeads are Sodium Alginate,
HPMC. Mucoadhesive microbeads were obtained by
Ionotropic gelation method for all the formulations from
F1 to F9. Formulations F1 to F9 were prepared with
different concentration of polymer and with constant
drug ratio of Rosuvastatin Calcium. All formulations
were evaluated for the Percentage yield, Particle size,
Drug content, Entrapment efficiency, Scanning electron
Microscopy, Swelling study, mucoadhesion testing, invitro drug release profile. From the overall studies it can
be concluded that the formulation F9 considered as the
best formulation among nine formulations by comparing
all the evaluated parameters.
Keywords :
Microbeads, Central Composite Design, Rosuvastatin calcium, in-vitro drug release studies.
The Mucoadhesive drug delivery system was
a new approach in pharmaceutical field and drug
retention for a prolonged time has been achieved.
Rosuvastatin calcium is a HMG-CoA Reductase
inhibitors (statins) used in the treatment of
percholesterolemia or hyperlipidemia. Mucoadhesive
micro beads of Rosuvastatin calcium were successfully
prepared by Ionotropic gelation technique. Central
composite design was applied for the preparation and
optimization of mucoadhesive microbeads using
Statease-Design of Experiment Version–12 software. The
results of preformulation studies showed that there was
no interaction between the drug and polymer. The
polymers used in the microbeads are Sodium Alginate,
HPMC. Mucoadhesive microbeads were obtained by
Ionotropic gelation method for all the formulations from
F1 to F9. Formulations F1 to F9 were prepared with
different concentration of polymer and with constant
drug ratio of Rosuvastatin Calcium. All formulations
were evaluated for the Percentage yield, Particle size,
Drug content, Entrapment efficiency, Scanning electron
Microscopy, Swelling study, mucoadhesion testing, invitro drug release profile. From the overall studies it can
be concluded that the formulation F9 considered as the
best formulation among nine formulations by comparing
all the evaluated parameters.
Keywords :
Microbeads, Central Composite Design, Rosuvastatin calcium, in-vitro drug release studies.
