Authors :
Khushi Setpalani; Deepak Pandit; Shraddha Vikraman Pillai; Suparna Ghosh
Volume/Issue :
Volume 9 - 2024, Issue 3 - March
Google Scholar :
https://tinyurl.com/2m526ewe
Scribd :
https://tinyurl.com/yckmy2k5
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24MAR074
Abstract :
The current study focuses on the synthesis and
the biological evaluation of Schiff base metal complex
produced from the diuretic drug Hydrochlorothiazide.
The bidentate ligand is produced by inserting
salicylaldehyde into a 1:1 molar ratio and condensing 6-
chloro-1,1-dioxo-3,4-dihydro-2H-1λ
6
,2,4-benzothiadiazine
-7-sulfonamide. Complex of Co(II) with general formula
ML2 have been produced using this bidentate ligand. We
examined the antibacterial properties of the produced
compounds. The results that were achieved were
compared with the original medicine,
hydrochlorothiazide. The compounds exhibited enhanced
antibacterial assay, with the Co(II) complex
demonstrating especially strong activity. The ligand and
its complex Co(II) were also screened for the invivo
Diuretic techniques.
Keywords :
Antimicrobial Assay, Diuretics, Diuretic Activity, Hydrochlorothiazide, Metal Ion Complex.
The current study focuses on the synthesis and
the biological evaluation of Schiff base metal complex
produced from the diuretic drug Hydrochlorothiazide.
The bidentate ligand is produced by inserting
salicylaldehyde into a 1:1 molar ratio and condensing 6-
chloro-1,1-dioxo-3,4-dihydro-2H-1λ
6
,2,4-benzothiadiazine
-7-sulfonamide. Complex of Co(II) with general formula
ML2 have been produced using this bidentate ligand. We
examined the antibacterial properties of the produced
compounds. The results that were achieved were
compared with the original medicine,
hydrochlorothiazide. The compounds exhibited enhanced
antibacterial assay, with the Co(II) complex
demonstrating especially strong activity. The ligand and
its complex Co(II) were also screened for the invivo
Diuretic techniques.
Keywords :
Antimicrobial Assay, Diuretics, Diuretic Activity, Hydrochlorothiazide, Metal Ion Complex.
