Study of the Effect of Different Additives on the Shelf Life of Microencapsulated Vitamin C


Authors : Makhlouf Nour; Harfouch Judi; Al Haushey Lama

Volume/Issue : Volume 9 - 2024, Issue 6 - June

Google Scholar : https://tinyurl.com/yc7bpf4z

Scribd : https://tinyurl.com/3ykfe6rt

DOI : https://doi.org/10.38124/ijisrt/IJISRT24JUN595

Abstract : Vitamin C (Vit C) is sensitive to oxidation, so maintaining its stability is the biggest challenge in its preparation and use. The aim of this research was to study the effect of adding various additives on the stability of Vit C microencapsulated in microparticles prepared by solvent evaporation method. The results showed that the system viscosity had an effect on the particle size, encapsulation efficiency EE was affected by PVA, Vit C and polymer concentrations. The additives that have shown a positive effect on EE are sucrose concentration, addition of alginate Na and chitosan. The results also showed that using (sucrose, glucose, cysteine, alginate Na and chitosan) as additives can protect AA in microparticles and increase shelf lives (AA shelf life increased significantly from 15 to 42 days by using sucrose as additive).

Keywords : Vit C, Shelf Life, Additives, Microencapsulation.

References :

  1. M.Ali Sheraz, S.Ahmed, M. Fatima Khan and S. Hafeez Kazi  “Stability and Stabilization of Ascorbic Acid Article “, 2015, pp:22
  2. B. N. Estevinho1, I.Carlan, A. Blaga2, F. Rocha1 “Soluble vitamins (vitamin B12 and vitamin C) microencapsulated with different biopolymer By a spray drying process” Powder Technology, 2016,  289, 71-78.
  3. V. Saxena1, K. Yadav2 2021 “Stability and Efficacy Enhancement of Vitamin C Powder via Developing a Serum Two Phase System, A New Inception in Vitamin C Delivery” International Journal of Research in Engineering, Science and Management Volume 4, Issue 2, February 2021.
  4. M.Ali Sheraz, S.Ahmed, M. Fatima Khan and S. Hafeez Kazi “Formulation and Stability of Ascorbic Acid in Topical Preparations “ July 2011 , p:86 (Researchgate).
  5. S. Sablani, K. Al-Belushi, I. Al-Marhubi & R. Al-Belushi   “Evaluating Stability of Vitamin C in Fortified Formula Using Water Activity and Glass Transition” 31 jan 2007. P:62. (International Journal of Food Properties).
  6. S.Abbas a , Chang Da Wei a, K.Hayat b & Z.Xiaoming a “Ascorbic Acid: Microencapsulation Techniques and Trends—A Review” 21 Feb 2012  (Food Reviews International).
  7. J.Domingues dos Santos Carvalho1 V. Boesso Oriani G.Marangoni de Oliveira, M.Dupas Hubinger1 “Solid Lipid Microparticles Loaded with Ascorbic Acid: Release Kinetic Profile During Thermal Stability”, April 2021. _(Journal of Food Processing and Preservation).
  8. Y-H P. Hsieh, N. D. Harris. “Effect of sucrose on oxygen uptake of ascorbic acid in a closed aqueous system” J Agric. Food Chem., 1993, 41, pp. 259-262.
  9. Francisco J. Salar 1, V.Agulló, , R.Domínguez-Perles and C.García-Viguera “Influence of Sweeteners (Sucrose, Sucralose, and Stevia) on Bioactive Compounds in a Model System Study for Citrus–Maqui Beverages” 29 july 2022 .
  10. L. Al haushey et al., “Improvement of a bovine serum albumin microencapsulation process by screening design”, Int J Pharm, 2007, 344, pp. 16-25.
  11.  AOAC. Official Methods of Analysis. 16th ed. Arlington, DC: Association of Official Analytical Chemists, 1984.
  12.  P. Ciancaglini, et al., “Using a classical method of vitamin C quantification as a tool for discussion of its role in the body”, Biochem. Molec. Biol. Edu., 2001, 29, pp. 110-114.s
  13. T. Sudhamani, K. Noveen kumarreddy, V.R. Ravi Kumar, R. Revathi, V. Ganesan, “Preparation and evaluation of ethyl cellulose microspheres of ibuprofen for sustained drug delivery”. IJPRD, 2010.
  14. L. Al haushey, N. Moussa, “The shelf life of vitamin C in a W/O emulsion according to the Q10 method”, Inter J Pharm Sci Rev Res., 2015, 30(2): 33-39. [ResearchGate].
  15. L. Al haushey, N. Moussa, “A study of the effect of the percentage and the components of the aqueous phase on the chemical stability of vitamin C n its dermal preparations”, inter J Pharm Sci Rev Res.2015, 31(2):149-154. [ResearchGate].
  16. B. Dolińska et al., “Influence of Trace Elements on Stabilization of Aqueous Solutions of Ascorbic Acid”, Biol Trace Elem Res. 2012, 150: 509–512. DOI 10.1007/s12011-012-9524-4.
  17. A-N, Yu, Y. Li, Y. Yang, K. Yu, “The browning kinetics of the non-enzymatic browning reaction in L-ascorbic acid/basic amino acid systems”, Food Sci Technol (Campinas). 2017, 38:537–42. doi: 10.1590/1678-457x.08717.
  18. B. Dolińska et al., “Influence of Trace Elements on Stabilization of Aqueous Solutions of Ascorbic Acid”, Biol Trace Elem Res. 2012, 150: 509–512.  
  19. Handbook of Pharmaceutical Excipients, Edited by Rowe, R. C., Sheskey, P. J., Quinn, M. E. 4th ed., Pharmaceutical Press, London, UK, (2009).
  20. P. Couvreur et al., “Multiple emulsion technology for the design of microspheres containing peptides and oligopeptides”, Adv Drug Deliv. Rev., 1997, 28, pp. 85-96.
  21. O. Ozer, V. Muguet, E. Roy, JL. Grossiord, M. Seiller. “Stability study of W/O/W viscosified multiple emulsions”, Drug Dev Ind Pharm, 2000, 26, pp. 1185-9.
  22. M. Szymula, “The influence of ascorbic acid on the rheological properties of the microemulsion region of the SDS/pentanol/water system”, J Cosmet Sci, 2005, 56, pp. 267-77.
  23. Kh. Sakeer, H. Al-Zein, “Studying the Effect of a Maltitol Solution on the Stability of Water Soluble Vitamins”, Jordan Journal of Pharmaceutical Sciences, 2012, 5, pp. 131-139.
  24. R. Abbasi, M. Jafari, M.  Fazel, “Potential of microencapsulation to protect ascorbic acid under different temperature and pH during heating process. Running head stability of microencapsulated ascorbic acid”, Braz. J. Technol., 2019, 2(2), pp. 573-589.
  25. S. Ray, U. Raychaudhuri, R. Chakraborty, “Food bioscience an overview of encapsulation of active compounds used in food products by drying technology”, Food Bioscience, 2016, 13, pp. 76–83.
  26. VK. Maurya, K. Bashir, M. Aggarwal, “Vitamin D microencapsulation and fortification: trends and technologies”, J Steroid Biochem Molecul Biol. 2020, 196:105489. .
  27. VK. Maurya, A. Shakya, K. Bashir, SC. Kushwaha, DJ. McClements, “Vitamin A fortification: recent advances in encapsulation technologies”, Comprehens Rev Food Sci Food Safety. 2022, 21:2772–819.
  28. JT. Dwyer, KL. Wiemer, O. Dary, CL. Keen, JC. King, KB. Miller, et al., “Fortification and health: challenges and opportunities”, Adv Nutr. 2015 6: pp. 124–31. doi: 10.3945/an.114.007443. 
  29. M. S. Uddin, M. N. A., Hawlader, L. Ding, A. S., Mujumdar. “degradation of ascorbic acid in dried guava during storage”, J. Food Eng.2002, 51, 21–26.
  30. S. S. Sablani, K. Al-Belushi, I. Al-Marhubi & R. Al-Belushi, “Evaluating Stability of Vitamin C in Fortified Formula Using Water Activity and Glass Transition”, International Journal of Food Properties, 2007, 10:1, pp. 61-71.
  31. A. M. Rojas, L. N. Gerschenson, “Ascorbic acid destruction in aqueous model systems: An additional discussion”, Journal of the Science of Food and Agriculture, 2001, 81(15), pp. 1433–1439.
  32. V. Palanisamy, P. Sanphui ,  k. Palanisamy ,  m. Prakash,  AK. Bansal, “Design of ascorbic acid eutectic mixtures with sugars to inhibit oxidative degradation”, Front. Chem., 2022, 10, pp. 1-10.
  33. R. J. Elias, D.J. McClements, E. A. Decker, “Antioxidant activity of cysteine, tryptophane, and methionine resudues in continuous phase B-lactoglobulin in oil-in-water emulsions”, Agri. Food Chem., 2005, 53 (26), pp. 10248-10253.
  34. F. Marcela, C. Lucía, F. Esther, M. Elena, “Microencapsulation of L-ascorbic acid by spray drying using sodium alginate as wall material”, J Encapsul Adsorp Sci. 2016, (6), pp. 1–8.
  35. A.Aresta, CD. Calvano, A. Trapani, S. Cellamare, CG. Zambonin, E. De Giglio, “Development and analytical characterization of vitamin(s)-loaded chitosan nanoparticles for potential food packaging applications”, J Nanoparticle Res. 2013, 15:1592.

Vitamin C (Vit C) is sensitive to oxidation, so maintaining its stability is the biggest challenge in its preparation and use. The aim of this research was to study the effect of adding various additives on the stability of Vit C microencapsulated in microparticles prepared by solvent evaporation method. The results showed that the system viscosity had an effect on the particle size, encapsulation efficiency EE was affected by PVA, Vit C and polymer concentrations. The additives that have shown a positive effect on EE are sucrose concentration, addition of alginate Na and chitosan. The results also showed that using (sucrose, glucose, cysteine, alginate Na and chitosan) as additives can protect AA in microparticles and increase shelf lives (AA shelf life increased significantly from 15 to 42 days by using sucrose as additive).

Keywords : Vit C, Shelf Life, Additives, Microencapsulation.

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.
Subscribe
OR

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.
Subscribe