Authors :
Elaf Ahmed Q., Mohamed Alfadil, Abazar M. Suliman, Awad A. Ali, Shahad O. Zaki, Wamdah Ahmed M.
Volume/Issue :
Volume 5 - 2020, Issue 1 - January
Google Scholar :
https://goo.gl/DF9R4u
Scribd :
https://bit.ly/3aKAnNb
Abstract :
Introduction
The aim of this study was to submit the ideal delay
period of Carbimazole for hyperthyroidism patients
using thyroid function test. It may be possible to
perform thyroid scan with a minimum delay period of
carbimazole, this can be time saving and decrease the
adverse effects of discontinuing carbimazole.
Patients and Methods
Among all the patients with hyperthyroidism who
referred to nuclear medicine department of Khartoum
Oncology Hospital, during the period between
December 2018 and December 2019, 51 patients who
were on Carbimazole were selected. A Thyroid
Function Test (TFT) was obtained while they ware on
medication for all these patients and then they were
divided into three groups upon TFT results each with
different Carbimazole delay period (A,B,C). We asked
each group; to discontinue the usage Carbimazole for 3,
5 and 7 days respectively and then a second TFT was
obtained. After that thyroid scan was performed for
these patients. Revealed data was analyzed under
supervision of statistical specialist with descriptive
methods on SPSS.
Results
11 patients were males and the other 40 were
females. Mean age of group A, B and C were 37 , 47 , 47
respectively. The mean of the first TFT (T3, T4 and
TSH) for group A was: (5.2, 225.59, 0.17), group B:
(5.28, 231.86, 0.13) and group C: (5.34, 246.19, 0.06).
While the mean of the second TFT (T3, T4, TSH) was
for group A: (6.33, 246.38, 0.03), group B: (9.18, 318.55,
0.05) and group C: (9.96, 381.72, 0.04). The mean of
thyroid uptake for group A, B and C was (21.35, 18.82
and 23.31) respectively. By comparing thyroid uptake
average from all the groups, the result showed that
thyroid uptake was not affected by the delay period.
While the second TFT results showed that there is a
direct linear association between T3 and T4 level and
the delay period; as the delay period increase T3 and T4
level increase, and TSH level decrease as the delay
period increases.
Discussion
In conclusion, we demonstrated that Carbimazole
3-days delay period does not interfere with reabsorbing
of Technetium-99m in thyroid gland and peripheral
tissues. A possible limitation of this study is the number
of patients in the sample. Therefore, it seems that it may
be possible to perform thyroid scan with a delay period
of 3 days rather than 5 or 7 days, this can be time saving
and decrease the adverse effects of discontinuing
Carbimazole.
Keywords :
Hyperthyroidism, Carbimazole, Thyroid Scan, TFT.
Introduction
The aim of this study was to submit the ideal delay
period of Carbimazole for hyperthyroidism patients
using thyroid function test. It may be possible to
perform thyroid scan with a minimum delay period of
carbimazole, this can be time saving and decrease the
adverse effects of discontinuing carbimazole.
Patients and Methods
Among all the patients with hyperthyroidism who
referred to nuclear medicine department of Khartoum
Oncology Hospital, during the period between
December 2018 and December 2019, 51 patients who
were on Carbimazole were selected. A Thyroid
Function Test (TFT) was obtained while they ware on
medication for all these patients and then they were
divided into three groups upon TFT results each with
different Carbimazole delay period (A,B,C). We asked
each group; to discontinue the usage Carbimazole for 3,
5 and 7 days respectively and then a second TFT was
obtained. After that thyroid scan was performed for
these patients. Revealed data was analyzed under
supervision of statistical specialist with descriptive
methods on SPSS.
Results
11 patients were males and the other 40 were
females. Mean age of group A, B and C were 37 , 47 , 47
respectively. The mean of the first TFT (T3, T4 and
TSH) for group A was: (5.2, 225.59, 0.17), group B:
(5.28, 231.86, 0.13) and group C: (5.34, 246.19, 0.06).
While the mean of the second TFT (T3, T4, TSH) was
for group A: (6.33, 246.38, 0.03), group B: (9.18, 318.55,
0.05) and group C: (9.96, 381.72, 0.04). The mean of
thyroid uptake for group A, B and C was (21.35, 18.82
and 23.31) respectively. By comparing thyroid uptake
average from all the groups, the result showed that
thyroid uptake was not affected by the delay period.
While the second TFT results showed that there is a
direct linear association between T3 and T4 level and
the delay period; as the delay period increase T3 and T4
level increase, and TSH level decrease as the delay
period increases.
Discussion
In conclusion, we demonstrated that Carbimazole
3-days delay period does not interfere with reabsorbing
of Technetium-99m in thyroid gland and peripheral
tissues. A possible limitation of this study is the number
of patients in the sample. Therefore, it seems that it may
be possible to perform thyroid scan with a delay period
of 3 days rather than 5 or 7 days, this can be time saving
and decrease the adverse effects of discontinuing
Carbimazole.
Keywords :
Hyperthyroidism, Carbimazole, Thyroid Scan, TFT.
