Authors :
Ye Ping; Zhou Wei
Volume/Issue :
Volume 10 - 2025, Issue 8 - August
Google Scholar :
https://tinyurl.com/3dmb7wyb
Scribd :
https://tinyurl.com/84yxabsv
DOI :
https://doi.org/10.38124/ijisrt/25aug1472
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Note : Google Scholar may take 30 to 40 days to display the article.
Abstract :
Chronic pelvic inflammatory disease (CPID) is a common gynecological infectious disease in women of
childbearing age. It is characterized by a long course and is difficult to cure. Traditional antibiotic treatment has limitations.
This prospective, randomized, controlled clinical trial evaluated the clinical efficacy of jingangteng tung combined with
doxycycline in the treatment of CPID and its effects on inflammatory factors. Sixty patients were randomly divided into an
experimental group (combination therapy group) and a control group (doxycycline monotherapy group), with 30 patients
in each group. Results showed that the total effective rate in the experimental group was 93.3%, significantly higher than
the 76.7% in the control group (P < 0.05). After treatment, serum levels of the inflammatory factors IL-6, TNF-α, and CRP
in the experimental group were significantly lower than those in the control group, while levels of the anti-inflammatory
factor IL-10 were significantly higher in the control group (P < 0.01). Combination therapy exerts a synergistic anti-
inflammatory effect by inhibiting the release of pro-inflammatory factors and promoting the expression of anti-
inflammatory factors, with a good safety profile. Studies have shown that the combination of Vatica chinensis and
doxycycline is safe and effective in treating CPID, and can significantly relieve symptoms, regulate inflammatory responses,
and reduce the risk of disease recurrence and sequelae, providing a clinical basis for the integrated treatment of CPID with
traditional Chinese and Western medicine.
Keywords :
Chronic Pelvic Inflammatory Disease; Rhizoma Cynanchifoliae; Doxycycline; Inflammatory Factors; Integrated Traditional Chinese and Western Medicine; Clinical Efficacy.
References :
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- Zhong Y, Ye P, Mei Z, et al., 2019, Molecular Immunology, 114: 179-188.
- Standardization Project Team of “Guidelines for the Clinical Application of Traditional Chinese Medicines in the Treatment of Advantageous Diseases”, 2021, Chinese Journal of Integrated Traditional and Western Medicine, 41(03): 286-299.
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- Hao Xia, Li Wei, 2021, Chinese Journal of Traditional Chinese Medicine, 39(11): 182-185.
- Qi J, Cui YN, 2018, Journal of Hainan Medical College, 24(13): 1219-1225+1225.
- Huang Xianzhang, Zou Pengcheng, Gao Qiufang, Feng Yun, Yi Ling, Liu Yanwen. 2010. Chinese Journal of Experimental Traditional Chinese Medicine, 16(17): 114-117.
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Chronic pelvic inflammatory disease (CPID) is a common gynecological infectious disease in women of
childbearing age. It is characterized by a long course and is difficult to cure. Traditional antibiotic treatment has limitations.
This prospective, randomized, controlled clinical trial evaluated the clinical efficacy of jingangteng tung combined with
doxycycline in the treatment of CPID and its effects on inflammatory factors. Sixty patients were randomly divided into an
experimental group (combination therapy group) and a control group (doxycycline monotherapy group), with 30 patients
in each group. Results showed that the total effective rate in the experimental group was 93.3%, significantly higher than
the 76.7% in the control group (P < 0.05). After treatment, serum levels of the inflammatory factors IL-6, TNF-α, and CRP
in the experimental group were significantly lower than those in the control group, while levels of the anti-inflammatory
factor IL-10 were significantly higher in the control group (P < 0.01). Combination therapy exerts a synergistic anti-
inflammatory effect by inhibiting the release of pro-inflammatory factors and promoting the expression of anti-
inflammatory factors, with a good safety profile. Studies have shown that the combination of Vatica chinensis and
doxycycline is safe and effective in treating CPID, and can significantly relieve symptoms, regulate inflammatory responses,
and reduce the risk of disease recurrence and sequelae, providing a clinical basis for the integrated treatment of CPID with
traditional Chinese and Western medicine.
Keywords :
Chronic Pelvic Inflammatory Disease; Rhizoma Cynanchifoliae; Doxycycline; Inflammatory Factors; Integrated Traditional Chinese and Western Medicine; Clinical Efficacy.
