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Subcutaneous Fat Lipolysis Injection and Its Efficacy: A Narrative Review and Example of Regentide-LLP53 as Successful Model


Authors : Leroy Lucano Sompotan

Volume/Issue : Volume 11 - 2026, Issue 2 - February


Google Scholar : https://tinyurl.com/36t86zz8

Scribd : https://tinyurl.com/5n7uast7

DOI : https://doi.org/10.38124/ijisrt/26feb1455

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : The landscape of cosmetic dermatology and non-surgical body contouring has undergone a significant transformation over the last decade, driven by the increasing demand for minimally invasive alternatives to traditional surgical lipoplasty. Subcutaneous injection lipolysis has emerged as a prominent modality for the reduction of localized fat deposits, utilizing biochemical agents to induce adipocyte destruction and metabolic clearance. The evolution of this field is characterized by a transition from broad-spectrum detergent-based solutions to more targeted formulations incorporating biomimetic peptides, glycerophospholipids, and xanthine derivatives. Injection lipolysis represents a robust and safe alternative for body contouring when applied to small to moderate localized fat deposits. As research continues to explore the potential of signaling peptides, Regentide LLP-053 stands as a proven example of how molecular biology can be harnessed to achieve precise aesthetic goals.

Keywords : Injection Lipolysis, Adipocyte, Biomimetic Peptide, Efficacy.

References :

  1. Lima TN, Pedriali Moraes CA. Bioactive peptides: applications and relevance for cosmeceuticals. Cosmetics. 2018;5(1):21.
  2. Hasengschwandtner F. Injection lipolysis for effective reduction of localized fat in place of minor surgical lipoplasty. Aesthetic Surg J. 2006;26(2):125–30.
  3. Grabner GF, Xie H, Schweiger M, Zechner R. Lipolysis: cellular mechanisms for lipid mobilization from fat stores. Nat Metab. 2021;3(11):1445–65.
  4. Katsi V, Koutsopoulos G, Fragoulis C, Dimitriadis K, Tsioufis K. Retatrutide—a game changer in obesity pharmacotherapy. Biomolecules. 2025;15(6):796.
  5. Thomas MK, D’Silva JA, Borole AJ. Injection lipolysis: a systematic review of literature and our experience with a combination of phosphatidylcholine and deoxycholate over a period of 14 years in 1269 patients of Indian and South East Asian origin. J Cutan Aesthet Surg. 2018;11(4):222–8.
  6. Cano-Barquilla P, Jiménez-Ortega V, Fernández-Mateos P, Virto L, Maldonado Bautista E, Perez-Miguelsanz J, et al. Daily lipolysis gene expression in male rat mesenteric adipose tissue: Obesity and melatonin effects. Int J Mol Sci. 2025;26(2):577.
  7. LIPO SHRINKER PPT (EN).pdf.
  8. Gazitaeva ZI, Drobintseva AO, Chung Y, Polyakova VO, Kvetnoy IM. Cosmeceutical product consisting of biomimetic peptides: antiaging effects in vivo and in vitro. Clin Cosmet Investig Dermatol. 2017;11–6.
  9. Park SY, Kim S, Wan J, Felice F, Yi K. Lipolytic agents for submental fat reduction. Ski Res Technol. 2024;30(2):e13601.
  10. Reeds DN, Mohammed BS, Klein S, Boswell CB, Young VL. Metabolic and structural effects of phosphatidylcholine and deoxycholate injections on subcutaneous fat: a randomized, controlled trial. Aesthetic Surg J. 2013;33(3):400–8.
  11. Rotunda AM, Suzuki H, Moy RL, Kolodney MS. Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation used for localized fat dissolution. Dermatologic Surg. 2004;30(7):1001–8.
  12. Klein SM, Schreml S, Nerlich M, Prantl L. In vitro studies investigating the effect of subcutaneous phosphatidylcholine injections in the 3T3-L1 adipocyte model: lipolysis or lipid dissolution? Plast Reconstr Surg. 2009;124(2):419–27.
  13. El Kamshoushy A, Abel Maksoud R, El Mahdy N. Evaluation of the efficacy of injection lipolysis using phosphatidylcholine/deoxycholate versus deoxycholate alone in treatment of localized fat deposits. J Clin Exp Dermatol. 2012;3(2):1–9.
  14. Piłat P, Szpila G, Stojko M, Nocoń J, Smolarczyk J, Żmudka K, et al. Modern and non-invasive methods of fat removal. Medicina (B Aires). 2023;59(8):1378.
  15. Abdi Dezfouli R, Hosseinpour A, Qorbani M, Daneshzad E. The efficacy of topical aminophylline in local fat reduction: A systematic review. Front Endocrinol (Lausanne). 2023;14:1087614.
  16. Hoefflin SM. Lipoplasty with hypotonic pharmacologic lipo-dissolution. Aesthetic Surg J. 2002;22(6):573–6.
  17. Caruso MK, Roberts AT, Bissoon L, Self KS, Guillot TS, Greenway FL. An evaluation of mesotherapy solutions for inducing lipolysis and treating cellulite. J Plast Reconstr aesthetic Surg. 2008;61(11):1321–4.
  18. Jung H. Hyaluronidase: An overview of its properties, applications, and side effects. Arch Plast Surg. 2020;47(04):297–300.
  19. Jegasothy SM. Deoxycholic acid injections for bra-line lipolysis. Dermatologic Surg. 2018;44(5):757–60.
  20. Shridharani SM. Improvement in jowl fat following ATX-101 treatment: results from a single-site study. Plast Reconstr Surg. 2020;145(4):929–35.
  21. Naeem M, Imran L, Banatwala UESS. Unleashing the power of retatrutide: A possible triumph over obesity and overweight: A correspondence. Heal Sci Reports. 2024;7(2):e1864.
  22. Abdrabou Abouelmagd A, Abdelrehim AM, Bashir MN, Abdelsalam F, Marey A, Tanas Y, et al. Efficacy and safety of retatrutide, a novel GLP-1, GIP, and glucagon receptor agonist for obesity treatment: a systematic review and meta-analysis of randomized controlled trials. In: Baylor University Medical Center Proceedings. Taylor & Francis; 2025. p. 291–303. 

The landscape of cosmetic dermatology and non-surgical body contouring has undergone a significant transformation over the last decade, driven by the increasing demand for minimally invasive alternatives to traditional surgical lipoplasty. Subcutaneous injection lipolysis has emerged as a prominent modality for the reduction of localized fat deposits, utilizing biochemical agents to induce adipocyte destruction and metabolic clearance. The evolution of this field is characterized by a transition from broad-spectrum detergent-based solutions to more targeted formulations incorporating biomimetic peptides, glycerophospholipids, and xanthine derivatives. Injection lipolysis represents a robust and safe alternative for body contouring when applied to small to moderate localized fat deposits. As research continues to explore the potential of signaling peptides, Regentide LLP-053 stands as a proven example of how molecular biology can be harnessed to achieve precise aesthetic goals.

Keywords : Injection Lipolysis, Adipocyte, Biomimetic Peptide, Efficacy.

Paper Submission Last Date
31 - March - 2026

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