DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) is a very rare and potentially fatal drug-induced delayed hypersensitivity syndrome. We present the case of a 60-year-old woman who had been on sulfasalazine for 2 months to treat rheumatoid arthritis. She was admitted for 4 days presenting a pruriginous maculopapular erythema predominantly on the trunk and fever of 39.5 °C. Blood tests showed marked eosinophilia (800/mm3), a cholestatic pattern, and severe inflammation. Sulfasalazine-induced DRESS syndrome was diagnosed.

Keywords : “DRESS Syndrome”, “Sulfasalazine Induced DRESS Syndrome”, “Sulfasalazine Adverse Effects”, “Sulfasalazine”