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Surgical Cytoreduction and Intraperitoneal Hyperthermic Chemotherapy for Delayed Pseudomyxoma Peritonei of Appendiceal Origin: A Case Study


Authors : Nupura Ajesh; Samiksha Ravindra Balaguragi

Volume/Issue : Volume 11 - 2026, Issue 2 - February

Google Scholar : https://tinyurl.com/24atb54e

Scribd : https://tinyurl.com/48mevx22

DOI : https://doi.org/10.38124/ijisrt/26feb1270

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Abstract : Background: Pseudomyxoma peritonei (PMP) is a rare peritoneal malignancy that is characterized by mucinous ascites and peritoneal surface implants, which usually originate from low grade appendiceal mucinous neoplasms (LAMN). Due to its indolent yet progressive nature, diagnosis is often delayed. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) remains the mainstay of management.  Case Presentation: We report a case of a patient previously treated with laparoscopic cholecystectomy and appendectomy for LAMN (T4N0M1) in 2022, who presented two years later with abdominal pain and abdominal wall abnormalities. Imaging revealed diffuse multicystic intraperitoneal masses, adhesions, and scalloping of visceral surfaces suggestive of PMP. The patient underwent extensive cytoreductive surgery, including exploratory laparotomy, partial colectomy with stapled anastomosis, partial gastrectomy, splenectomy, and peritoneal resections, followed by HIPEC. Postoperative recovery was uneventful, with gradual reintroduction of oral feeding and multidisciplinary follow up.  Conclusion: This case sheds light on the importance of early detection. Accurate imaging and comprehensive surgical management in PMP. CRS combined with HIPEC gives the best shot in long term control, mainly in cases that are secondary to LAMN. Long term follow up remains crucial as there is a risk of delayed progression.

Keywords : Pseudomyxoma Peritonei; Low-Grade Appendiceal Mucinous Neoplasm; Cytoreductive Surgery; HIPEC; Peritoneal Surface Malignancy; Case Report.

References :

  1. Miguez González, J., Calaf Forn, F., Pelegrí Martínez, L., Lozano Arranz, P., Oliveira Caiafa, R., Català Forteza, J., Palacio Arteaga, L. M., Losa Gaspà, F., Ramos Bernadó, I., Barrios Sánchez, P., & Ayuso Colella, J. R. (2023). Primary and secondary tumors of the peritoneum: key imaging features and differential diagnosis with surgical and pathological correlation. Insights into imaging, 14(1), 115. https://doi.org/10.1186/s13244-023-01417-6
  2. Usenko O, Voitiv Y, Vladyslav K, Andrii B, Makarov V, Ivan R. Laparoscopic cecal pole resection for LAMN a case report. Int J Surg Case Rep. Published online November 16, 2024. doi: 10.1016/j.ijscr.2024.110625
  3. Lu C, Embel VK, Fox ME, Donne R, Parker GS. Diagnostic uncertainty and management of low-grade appendiceal mucinous neoplasm-a case report and review of the literature. J Surg Case Rep. 2024;2024(11): rjae717. Published 2024 Nov 18. doi:10.1093/jscr/rjae717
  4. Lu C, Embel VK, Fox ME, Donne R, Parker GS. Diagnostic uncertainty and management of low-grade appendiceal mucinous neoplasm-a case report and review of the literature. J Surg Case Rep. 2024;2024(11): rjae717. Published 2024 Nov 18. doi:10.1093/jscr/rjae717
  5. Gao SC, Ma JH, Kong H, Ma RQ, Chen SL, Wang DX. Intraoperative hyperthermia is associated with increased acute kidney injury following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a retrospective cohort study. Ren Fail. 2024;46(2):2420835. doi:10.1080/0886022X.2024.2420835
  6. Louis M, Gibson B, Chambers J. Optimal Surgical Approaches for Incidentally Discovered Ruptured Mucinous Appendiceal Neoplasms. Cureus. 2024;16(10): e70808. Published 2024 Oct 4. doi:10.7759/cureus.70808
  7. Aguilar-Ruiz F, Fuentes-Calvo KJ, Arechavala-Lopez SF, Fuentes-Calvo I, Arias-Ruiz LF. Incidental Appendiceal Mucinous Neoplasm Found During Appendectomy in a 15-Year-Old Patient: A Case Report. Cureus. 2024;16(9): e70350. Published 2024 Sep 27. doi:10.7759/cureus.70350
  8. Gibson J, Pengelly RJ, Mirandari A, et al. Targeted Genetic Sequencing Analysis of 223 Cases of Pseudomyxoma Peritonei Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Shows Survival Related to GNAS and KRAS Status. Cancer Med. 2024;13(20): e70340. doi:10.1002/cam4.70340
  9. Mousa AH, Nukaly HY, Samman RR, et al. Pseudomyxoma peritonei of appendiceal mucinous neoplasm origin: A case report and review of literature. Radiol Case Rep. 2024;19(12):6565-6573. Published 2024 Sep 28. doi: 10.1016/j.radcr.2024.08.158
  10. Alkheder A, Fathallah I, Alajrd AA, Alsodi Z, Rahal MAK. Incidental discovery of asymptomatic low-grade mucinous appendiceal tumor during paraumbilical hernia repair: A case report emphasizing intraoperative vigilance. Int J Surg Case Rep. 2024; 123:110329. doi: 10.1016/j.ijscr.2024.110329

Background: Pseudomyxoma peritonei (PMP) is a rare peritoneal malignancy that is characterized by mucinous ascites and peritoneal surface implants, which usually originate from low grade appendiceal mucinous neoplasms (LAMN). Due to its indolent yet progressive nature, diagnosis is often delayed. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) remains the mainstay of management.  Case Presentation: We report a case of a patient previously treated with laparoscopic cholecystectomy and appendectomy for LAMN (T4N0M1) in 2022, who presented two years later with abdominal pain and abdominal wall abnormalities. Imaging revealed diffuse multicystic intraperitoneal masses, adhesions, and scalloping of visceral surfaces suggestive of PMP. The patient underwent extensive cytoreductive surgery, including exploratory laparotomy, partial colectomy with stapled anastomosis, partial gastrectomy, splenectomy, and peritoneal resections, followed by HIPEC. Postoperative recovery was uneventful, with gradual reintroduction of oral feeding and multidisciplinary follow up.  Conclusion: This case sheds light on the importance of early detection. Accurate imaging and comprehensive surgical management in PMP. CRS combined with HIPEC gives the best shot in long term control, mainly in cases that are secondary to LAMN. Long term follow up remains crucial as there is a risk of delayed progression.

Keywords : Pseudomyxoma Peritonei; Low-Grade Appendiceal Mucinous Neoplasm; Cytoreductive Surgery; HIPEC; Peritoneal Surface Malignancy; Case Report.

Paper Submission Last Date
31 - March - 2026

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