Synthesis and Biological Evaluation of N-(4-(Morpholine-4-Carbonyl)Thiazol-2-yl)-2- (piperazin-1-yl) Acetamide Hydrochloride and Their Sulfonamide Derivatives


Authors : Shrikant S. Gawandea; Parag S. Kurleb; Jayshree Parikhb; Vijay H. Pethab; Bharti P. Deshmukhb

Volume/Issue : Volume 8 - 2023, Issue 6 - June

Google Scholar : https://bit.ly/3TmGbDi

Scribd : https://tinyurl.com/y4c9xsdz

DOI : https://doi.org/10.5281/zenodo.8162453

Abstract : A series of novel heterocyclic hybrids, N-(4- (morpholine-4-carbonyl) thiazol-2-yl)-2-(piperazin-1-yl) acetamide hydrochloride and its sulfonamide derivatives were synthesized (compound 6a-j) and their structure was established with the facility of spectroscopic techniques such as FTIR, 13C NMR, 1H NMR, Mass, etc. In-vitro antibacterial, antifungal, and antioxidant activities of the synthesized compounds 6a-j have been evaluated by using ampicillin, Nystatin, and Ascorbic acid as the reference standards. Compounds 6b, 6c, 6e, 6g, and 6j have revealed comparable antibacterial activity by displaying similar MIC values as the reference standard used. Although antioxidant activities are seen as ordinary compared to the reference standard, interestingly compounds 6b, 6e, and 6g have displayed multi-target inhibitory action against different microbial, making it a possible choice as a single drug for the cater of multiple ailments.

A series of novel heterocyclic hybrids, N-(4- (morpholine-4-carbonyl) thiazol-2-yl)-2-(piperazin-1-yl) acetamide hydrochloride and its sulfonamide derivatives were synthesized (compound 6a-j) and their structure was established with the facility of spectroscopic techniques such as FTIR, 13C NMR, 1H NMR, Mass, etc. In-vitro antibacterial, antifungal, and antioxidant activities of the synthesized compounds 6a-j have been evaluated by using ampicillin, Nystatin, and Ascorbic acid as the reference standards. Compounds 6b, 6c, 6e, 6g, and 6j have revealed comparable antibacterial activity by displaying similar MIC values as the reference standard used. Although antioxidant activities are seen as ordinary compared to the reference standard, interestingly compounds 6b, 6e, and 6g have displayed multi-target inhibitory action against different microbial, making it a possible choice as a single drug for the cater of multiple ailments.

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