Sulphamethoxazole and trimethoprim mixed ligand and their Mn(II) and Cu(II) metal complexes have been synthesized and characterized. The characterization of metal complexes is based on the results of the solubility, colour, melting points and spectroscopic studies. The UVVisible spectra revealed characteristic wavelength maxima at 600 nm, 700 nm, 750 nm and 800 nm assigned to the d-d electronic transition of the metal complexes. The FTIR results confirmed that the manganese and copper ions coordinated through the nitrogen atom and oxygen atom (S=O) of sulphamethoxazole and through the nitrogen atoms in trimethoprim. The antimicrobial activities of the metal complexes synthesized indicated that the metal complexes were more potent against selected organisms than the free ligands.

Keywords : Sulphamethoxazole, Trimethoprim, Mixed ligands, Metal complexes, Antimicrobial activities, Spectra studies, Characterization.