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Synthesis, Characterization and DNA Binding Studies of Cu(II), Co(II) and Ni(II) Chelates Derived from a 5-Bromosalicylaldehyde–Pyridine Schiff Base Ligand


Authors : Ereshanaik; M. C. Prabhakara; Nagendra Naik K.; B. K. Nagaraja

Volume/Issue : Volume 11 - 2026, Issue 8 - August


Google Scholar : https://tinyurl.com/3rtr3fz2

DOI : https://doi.org/10.38124/ijisrt/26aug997

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : We detailed the synthesis and comprehensive characterization of a novel Schiff base ligand, 3-[(E)-(5-bromo-2- hydroxyphenyl)methylidene]amino)pyridin-4-ol, and its coordination complexes with Cu(II), Co(II), and Ni(II) ions. The ligand was synthesized via one-pot condensation of 5-bromosalicylaldehyde and 3-amino-4-hydroxypyridine and further chelated with transition metal chlorides.

Keywords : Schiff Base Ligand; Metal Chelates; DNA Cleavage; Pyridine Derivatives; Copper(II), Cobalt(II), Nickel(II) Complexes.

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We detailed the synthesis and comprehensive characterization of a novel Schiff base ligand, 3-[(E)-(5-bromo-2- hydroxyphenyl)methylidene]amino)pyridin-4-ol, and its coordination complexes with Cu(II), Co(II), and Ni(II) ions. The ligand was synthesized via one-pot condensation of 5-bromosalicylaldehyde and 3-amino-4-hydroxypyridine and further chelated with transition metal chlorides.

Keywords : Schiff Base Ligand; Metal Chelates; DNA Cleavage; Pyridine Derivatives; Copper(II), Cobalt(II), Nickel(II) Complexes.

Paper Submission Last Date
31 - October - 2026

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