The anti- inflammatory, analgesic, &
antipyretic drugs are a heterogeneous group of
compounds, often chemically unrelated (although most
of them are organic acids), which nevertheless share
certain therapeutic actions & side effects. The prototype
is aspirin; hence these compounds are also referred to as
aspirin- like drugs; they are also frequently called as
Non Steroidal anti-inflammatory drugs, or NSAID’s.
The pyrrole derivatives have been shown to have varying
degree of analgesic, anti-inflammatory, & antipyretic
activities (1, 10)
. On the basis of this observation the
present work was designed to synthesize some pyrrole
derivative conjugates with some standard NSAID’s &
evaluate those conjugates for their anti-inflammatory
activity. There are tremendous possibilities that such
conjugates may be useful in the treatment of various
inflammatory disorders, with lower incidence of GI
ulceration. This may be due to the presence of pyrrole
ring which acts as the basic template of COX-2
inhibition and not COX-1 which protects the GI tract.
Keywords : Pyrrole, Anti Inflammatory, COX, NASID’S.