Synthesis & Evaluation of Pyrrole Derivative Conjugates as Effective Nsaid’s

Authors : Chaturvedi Saurabh; Nama Nitin; Jain Harshita.

Volume/Issue : Volume 6 - 2021, Issue 7 - July

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The anti- inflammatory, analgesic, & antipyretic drugs are a heterogeneous group of compounds, often chemically unrelated (although most of them are organic acids), which nevertheless share certain therapeutic actions & side effects. The prototype is aspirin; hence these compounds are also referred to as aspirin- like drugs; they are also frequently called as Non Steroidal anti-inflammatory drugs, or NSAID’s. The pyrrole derivatives have been shown to have varying degree of analgesic, anti-inflammatory, & antipyretic activities (1, 10) . On the basis of this observation the present work was designed to synthesize some pyrrole derivative conjugates with some standard NSAID’s & evaluate those conjugates for their anti-inflammatory activity. There are tremendous possibilities that such conjugates may be useful in the treatment of various inflammatory disorders, with lower incidence of GI ulceration. This may be due to the presence of pyrrole ring which acts as the basic template of COX-2 inhibition and not COX-1 which protects the GI tract.

Keywords : Pyrrole, Anti Inflammatory, COX, NASID’S.


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