Phenyl hydroxyl amine & glutaraldehyde are synthesizing and it has been yielded simple stable form of nitrone. It has been playing an essential part to synthesis the heterocyclic compounds that undergoes the elegant characteristic transformation. Nitrones can be used as probable oxidizing reagents through the renovation of several alkyl halides to ketones and aldehydes with high crop. The novel nitrone is 1,3-Dipole and its used in 1,3-dipolar cycloaddition. The 1,3- dipolar cycloaddition of nitrones with numerous dipolarophiles creates some heterocyclic rings having different sizes and incalculable N-heterocyclic motifs. That has been contains the extensively existed molecules in the biological or pharmaceutical interest. In the present research it has been evaluate a competent method for synthesis of α-Glutaryl-N-aryl nitrone and its employed for their antimicrobial activities and it is confirmed in 13C and 1H NMR techniques.

Keywords : α-Glutaryl-N-Aryl Nitrone; Glutaraldehyde; Phenyl Hydroxyl Amine; 1,3 Cycloadditions; Anti-Microbial Activities