Authors :
Vahid Hosseini; Seyed Masoud Ghoreishi Mokri; Kadomtseva Alena Viktorovna
Volume/Issue :
Volume 9 - 2024, Issue 4 - April
Google Scholar :
https://tinyurl.com/47n27hhx
Scribd :
https://tinyurl.com/2uw37zab
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24APR201
Abstract :
Billions of dollars are spent annually in the
world to treat and investigate problems caused by drug
side effects. According to the estimation of health
researchers, a huge part of people who take medicine
suffer from complications caused by it. In this way, the
necessity of using a targeted system in order to deliver
medicine to the targeted place without damaging healthy
tissues is felt more than before. In recent years, targeted
drug delivery systems based on nanoparticles have
received much attention. In the same direction, in this
research, co-precipitation method was used to prepare
magnetic nanoparticles using iron(|) and iron(||) oxides,
and further, according to the synthesis steps of magnetite
nanoparticles (MNPs) and the mechanism of formation
and identification of magnetite nanoparticles ( Fe3O4) by
examining the infrared pattern (FT-IR) obtained from
Fe3O4 nanoparticles, the results of the magnetometric test
(VSM) of Fe3O4 nanoparticles, X-ray diffraction pattern
(XRD) of Fe3O4 nanoparticles, Field Emission Scanning
Electron Microscope (FE-SEM) images obtained from
Fe3O4 nanoparticles was discussed. After this stage, silica-
coated iron nanoparticles (Fe3O4@SiO2) were prepared,
and the infrared (FT-IR) pattern of Fe3O4@SiO2) was also
investigated. It is worth mentioning that the mechanism
of formation and identification of magnetic silica-coated
iron nanoparticles (Fe3O4@SiO2) has been described in
detail. Therefore, the obtained results indicate that the
drug can be guided in a controlled and targeted manner
by the magnetic field, and the results of the FE-SEM
images show that the obtained product has a spherical
morphology and the particle size distribution was less
than 100 nm. Therefore, spherical shape and the
symmetry of these particles can be helpful for their
movement in the liquid mediu.
Keywords :
Targeted Drug Delivery - Magnetite Nanoparticle - Co-Precipitation Method - Silica Coating
Billions of dollars are spent annually in the
world to treat and investigate problems caused by drug
side effects. According to the estimation of health
researchers, a huge part of people who take medicine
suffer from complications caused by it. In this way, the
necessity of using a targeted system in order to deliver
medicine to the targeted place without damaging healthy
tissues is felt more than before. In recent years, targeted
drug delivery systems based on nanoparticles have
received much attention. In the same direction, in this
research, co-precipitation method was used to prepare
magnetic nanoparticles using iron(|) and iron(||) oxides,
and further, according to the synthesis steps of magnetite
nanoparticles (MNPs) and the mechanism of formation
and identification of magnetite nanoparticles ( Fe3O4) by
examining the infrared pattern (FT-IR) obtained from
Fe3O4 nanoparticles, the results of the magnetometric test
(VSM) of Fe3O4 nanoparticles, X-ray diffraction pattern
(XRD) of Fe3O4 nanoparticles, Field Emission Scanning
Electron Microscope (FE-SEM) images obtained from
Fe3O4 nanoparticles was discussed. After this stage, silica-
coated iron nanoparticles (Fe3O4@SiO2) were prepared,
and the infrared (FT-IR) pattern of Fe3O4@SiO2) was also
investigated. It is worth mentioning that the mechanism
of formation and identification of magnetic silica-coated
iron nanoparticles (Fe3O4@SiO2) has been described in
detail. Therefore, the obtained results indicate that the
drug can be guided in a controlled and targeted manner
by the magnetic field, and the results of the FE-SEM
images show that the obtained product has a spherical
morphology and the particle size distribution was less
than 100 nm. Therefore, spherical shape and the
symmetry of these particles can be helpful for their
movement in the liquid mediu.
Keywords :
Targeted Drug Delivery - Magnetite Nanoparticle - Co-Precipitation Method - Silica Coating
