This research aimed to explore the experiences of teachers in integrating 21stCentury skills in the Science classrooms of the Sisters of Mary Schools - Philippines.The respondents were selected using the purposive sampling. Science teachers ofGirlstown and Boystown campuses were preferred participants. A total of 5respondents agreed to participate in the focus group discussion. Five themes weregenerated answering research question 1 and 2. These themes were impulsion,undergoing, doing, emotional experience, and obstacle. On the other hand, four themes emerged for question number 3. They are training and seminars, alignmentof expertise to teaching load, assessment tools, and motivational programs forstudents.The findings of the study were used as a basis for forwardingrecommendations so that 21st Century skills integration in the classroom will besuccessfully implemented.

Keywords : Teachers Experiences, 21st Century skills, and Science Classroom.