The aim of the study was to assess the antibacterial effect of Momordica charantia plant extracts and of extracts in combination with antibiotic drugs against Escherichia coli and Staphylococcus aureus. The aqueous and ethanolic extracts of Momordica charantia leaves were prepared using water reflux and soxhalation respectively. The antibacterial activities of extracts were evaluated using the well diffusion method and the inhibitory zones were recorded in millimeters. The effect of combination of Momordica charantia plant extracts and antibiotics drugs was assessed using well diffusion method.The results of this study showed that ethanolic extract of Momordica charantia exhibited better antibacterial activity against E. coli and. S. aureus than the aqueous extract. Also synergistic antibacterial effect was observed by both aqueous and ethanolic extracts of Momordica charantia with antibiotic drugs cefotaxime and ceftriaxone. However ethanolic extract in combination of both the anitiobiotic drugs showed better antibacterial results than that with aqueous extracts . Thereby, our results indicate the possibility of using aqueous and ethanolic extracts of Momordica charantia in the treatment of bacterial infections. Also these extracts showed promising results to be used in combination with synthetic antibiotics to give synergistic antibacterial effect. However there is need for clinical studies to determine the real effectiveness and potential toxic effects in vivo. These results revealed the importance of plant extracts when associated with antibiotic drugs in control of bacteria.