The morphology and volume of the brain in TLE patients, especially hippocampus, amygdala, were displayed by cMRI scan, EEG and post-processing of 3D T1WI. Methods: A total of 69 epileptic patients aged 18-60 years were collected for re-evaluation, including EEG, routine cMRI scan and 3D T1WI scan of the whole brain on 1.5T and 3.0T MRI. The 3D T1WI was further post-processed by VBM. Results: In 1.5T MRI group, 30% were MRI negative. 20% showed the reduction of left hippocampal volume, 10% showed the reduction of right hippocampus, and 10% showed reduction of left amygdala, and consistent with the location of EEG. The right hippocampus showed a difference in the volume of patients with control group. In 3.0T MRI group, only 10% had TLE. In 3 cases of TLE, the volume of bilateral hippocampus in 33.33% patients was smaller than control and consistent with the location of EEG. Conclusion: VBM combined with EEG and cMRI can provide detailed information for epileptics and helps in analysis of ROI structure, accurately measures and calculate the volumes.

Keywords : Epilepsy, Temporal Lobe Epilepsy (TLE), Conventional MRI (cMRI), Electroencephalography (EEG), Voxel Based Morphometry (VBM), Postprocessing, Region of interest (ROI)