The Comparative Study of Albendazole and Euphorbia thymifolia for Anthelmintic Activity

Authors : Pratiksha S. Dhembare; Pratiksha K. Dange; Rohan A. Dhamane; Sanket B. Chopade; Sandeep R.Kane; Shrinivas K. Mohite

Volume/Issue : Volume 8 - 2023, Issue 1 - January

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Nanoparticles are defined as particles with one or more dimensions and sizes between one and one hundred nanometers (nm) by ISO and ASTM standards. Due to their special qualities, silver nanoparticles have a wide range of uses, including antibacterial, anticancer, larvicidal, catalytic, and wound healing processes. Any medication that treats parasitic worm-related infections is known as an anthelmintic (helminthes). An established anthelmintic medication is Albendazole. Certain tapeworm infections are treated with the drug Albendazole (such as neurocysticercosis and hydatid disease). The centrifugation method wasused for 3 hours and 34 hours, respectively, to manufacture silver nanoparticles from Albendazole and Euphorbia thymifolia. Pheretima posthuma, an Indian earthworm, was tested for anthelmintic activity using Albendazole and Euphorbia thymifolia nanoparticles in ethanol. The results were stated for paralysis and bacterial death time after monitoring various concentrations of both Albendazole and Euphorbia thymifolia. Both plants' dose-dependent activity was seen. However, the synthetic medicineAlbendazole exhibits greater activity than the herbal drug Euphorbia thymifolia. It was determined thatboth the synthetic and natural medicines had anthelmintic activity, withAlbendazole having more of aneffect thanEuphorbia thymifolia.

Keywords : Nanoparticle Synthesis, Silver Nanoparticles, Albendazole, Euphorbia Thymifolia, and Anthelmintic Activity.


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