Authors :
Dr. Muhammad Israr Khan; Dr. Shumaila Ghazan; Dr. Maryam Munir; Dr. Muhib Ullah
Volume/Issue :
Volume 7 - 2022, Issue 11 - November
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3H84UXS
DOI :
https://doi.org/10.5281/zenodo.7395155
Abstract :
Introduction: Globally, over 2 million
colorectal cancer cases were diagnosed. It is the second
most common cause of cancer fatalities, causing 1 million
deaths annually. The current study aimed to compare
surgery and chemoradiotherapy treatment outcomes in
colorectal cancer recurrence. Method: The current study
was conducted using a randomized clinical trial design.
The study was carried out at Hayatabad Medical Complex,
Peshawar. A total of 74 patients previously treated for
colorectal cancer, were selected. The patients who showed
recurrence, based on radiology results, were selected for
the current study. Survival from the commencement of
chemoradiotherapy/surgery to death from any cause or
censoring at the final follow-up was defined as overall
survival (OS). OS were calculated using the Kaplan–Meier
technique and compared with the log-rank test. All
analyses were conducted using SPSS v25 and Jamovi.
Result: A total of 21 patient included in the final analysis.
The mean age in the surgery group was quite higher than
the chemoradiotherapy group (p = 0.31). The male to
female ratio in each group was 12/4, 8/3 respectively. The
timer size was quite higher than the chemoradiotherapy
group (p = 0.20). Two patients were died in the
chemoradiotherapy group while one patient was died in
surgery group. The survival rate of the surgery was quite
good as compared to the chemoradiotherapy group. In the
chemoradiotherapy group the patients survived up to 30
months, however, the patient treats with surgery showed
the longest survival. Conclusion: The current study
compared the surgery and Chemo-radio therapy in locally
recurrent colorectal cancer. Two patients in the
chemoradiotherapy group and one in the surgery group
was died. Compared to those who had chemoradiation,
surgical patients had a much higher chance of survival. In
the chemoradiotherapy group, patients lived up to 30
months; nevertheless, the surgical group had the longest
survival rate
Keywords :
Colorectal Cancer, Recurrence, Chemoradiotherapy, Surgery.
Introduction: Globally, over 2 million
colorectal cancer cases were diagnosed. It is the second
most common cause of cancer fatalities, causing 1 million
deaths annually. The current study aimed to compare
surgery and chemoradiotherapy treatment outcomes in
colorectal cancer recurrence. Method: The current study
was conducted using a randomized clinical trial design.
The study was carried out at Hayatabad Medical Complex,
Peshawar. A total of 74 patients previously treated for
colorectal cancer, were selected. The patients who showed
recurrence, based on radiology results, were selected for
the current study. Survival from the commencement of
chemoradiotherapy/surgery to death from any cause or
censoring at the final follow-up was defined as overall
survival (OS). OS were calculated using the Kaplan–Meier
technique and compared with the log-rank test. All
analyses were conducted using SPSS v25 and Jamovi.
Result: A total of 21 patient included in the final analysis.
The mean age in the surgery group was quite higher than
the chemoradiotherapy group (p = 0.31). The male to
female ratio in each group was 12/4, 8/3 respectively. The
timer size was quite higher than the chemoradiotherapy
group (p = 0.20). Two patients were died in the
chemoradiotherapy group while one patient was died in
surgery group. The survival rate of the surgery was quite
good as compared to the chemoradiotherapy group. In the
chemoradiotherapy group the patients survived up to 30
months, however, the patient treats with surgery showed
the longest survival. Conclusion: The current study
compared the surgery and Chemo-radio therapy in locally
recurrent colorectal cancer. Two patients in the
chemoradiotherapy group and one in the surgery group
was died. Compared to those who had chemoradiation,
surgical patients had a much higher chance of survival. In
the chemoradiotherapy group, patients lived up to 30
months; nevertheless, the surgical group had the longest
survival rate
Keywords :
Colorectal Cancer, Recurrence, Chemoradiotherapy, Surgery.
