Authors : Srinidhi Nagunuri; Dr. Sarah Daly

Volume/Issue : Volume 11 - 2026, Issue 9 - September

Google Scholar : https://tinyurl.com/3fudhfu3

DOI : https://doi.org/10.38124/ijisrt/26sep016

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : This investigation looked at whether the OLR1 gene plays a role in coronary artery disease. This was done by examining whether OLR1 RNA would be detectable in human coronary plaque tissue using NCBI Blast against RNA sequencing data. Coronary artery disease develops when cholesterol, lipids, and inflammatory cells build up in the coronary arteries, and OLRI is a key gene involved with the disease since it plays a role in oxidized LDL uptake and foam-cell formation. The human OLR1 mRNA sequence was confirmed through BLAST and then compared to data from experiment SRX20907944, an RNA‑seq dataset from human coronary‑plaque tissue of people affected by the disease. The BLAST search produced 150‑base alignments with 98.64%–100% identity and extremely small E‑values (as low as 1 × 10⁻⁶⁹), demonstrating that OLR1 transcripts were present in the plaque sample. A separate BLAST analysis also detected OLR1 RNA in diseased aortic‑valve tissue affected by calcific aortic valve disease, with 100% identity matches and E‑values down to 2 × 10⁻⁶⁹. These findings support the hypothesis that OLR1 is found in atherosclerotic tissue and show that the gene plays a role in not only coronary artery disease, but also calcific aortic valve disease.

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